ArticleJournal of the American Heart Association2025
Sex Differences in the Impact of Atherosclerotic Cardiovascular Risk Burden on Cognitive Health.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Sex-specific insights in atherosclerosis and pulmonary arterial hypertension: an overlooked comorbidity.Frontiers in cardiovascular medicine · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex affects the prevalence of atherosclerotic cardiovascular disease (ASCVD) risk factors but whether sex differences exist in the associations between ASCVD risk burden and cognitive function is unclear.
methodsThis cross-sectional study included participants from a population-based cohort study in China that recruited community-dwelling adults aged 50 to 75 years without baseline cardiovascular disease and stroke. The 10-year ASCVD risk burden was quantified with 3 multivariate risk prediction equations. Cognitive domains of memory, attention, visuospatial function, executive function, and processing speed were assessed. Multivariable linear regression models were used to examine the interaction terms between sex and ASCVD risk scores on cognition.
resultsThe final analytical sample included 2180 participants. Mean±SD age was 60.14 (6.38) and 52.1% were women. Men showed significantly higher ASCVD risk burden than women at baseline but the effect of ASCVD risk on 2-year cognition were amplified in women compared with men, for the domains of memory (eg, β=-0.20 [95% CI, -0.26 to -0.13] versus β=-0.11 [95% CI, -0.16 to -0.07]), executive function (eg, β=-0.23 [95% CI, -0.31 to -0.16] versus β=-0.16 [95% CI, -0.21 to -0.10]), and processing speed (eg, β=-0.33 [95% CI, -0.39 to -0.27] versus β=-0.17 [95% CI, -0.21 to -0.13]). Sex-stratified analyses showed different neuropsychological profiles at moderate ASCVD risk burden levels, suggesting sex-specific ASCVD-risk related cognitive phenotypes.
conclusionsSex differences in cognitive health affected by ASCVD risk underscore the importance of sex-specific cognitive monitoring during ASCVD risk management and better vascular risk control in women to prevent cognitive decline.
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