ReviewCellular and molecular life sciences : CMLS2025
Wnt signaling - using the bloodstream to send a message.
Review in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Skeletal Stem Cells Rescue Radiation-Induced Osteogenic Precursor Cell Dysfunction via the Wnt/β-Catenin Signaling Pathway.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Wnt signaling is one of the cell's most complex and important signal transduction pathways. This pathway, which is divided into additional sub-pathways, regulates cell growth, motility, polarity, and differentiation during embryonic development as well as stem cell regeneration. In addition, the Wnt cascades are involved in maintaining different aspects of adult homeostasis. The Wnt ligands, which normally initiate this cascade, are secreted glycoproteins that bind specific receptors and co-receptors to execute their intracellular signaling activity. The Wnt pathways have been extensively studied in anchored cells and in tissues. However, recent evidence now shows that the Wnt cascades are functional in the circulation and that these important signals can affect different circulating blood cells by traveling through the bloodstream. Wnt signaling can function in both paracrine and autocrine manner; however, in the current review, we will discuss the exocrine properties of the pathway and address the following topics: the source of Wnt ligands and their ability to travel in the bloodstream; which cell populations express Wnt signaling components; and finally, what are the physiological roles of the Wnt cascade in the different circulating blood cells.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.