ArticleJournal of molecular histology2025
Therapeutic potential of Angelica sinensis derivatized carbon dots in ameliorating chemotherapy-induced anemia.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research Progress on the Immunomodulatory Effects by Dang Gui (Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aplastic anemia, a prevalent disorder of the hematopoietic system, may develop as a result of bone marrow suppression induced by chemotherapeutic agents. Given its iatrogenic nature, the identification of affordable and effective therapeutic interventions remains a clinical priority. Angelica sinensis Radix (ASR) has been widely utilized in traditional Chinese medicine for anemia management and is supported by extensive clinical application. The aim of the present study is to examine the physicochemical characteristics of A. sinensis Radix-derived carbon dots (ASR-CDs) and to evaluate their therapeutic effects on hematopoietic injury in murine models exposed to chemotherapeutic agents. ASR-CDs were synthesized via calcination of ASR. The resulting nanomaterials were characterized in terms of particle morphology and surface functional groups. A Cell Counting Kit-8 (CCK-8) assay was used to assess biocompatibility. A zebrafish anemia model was employed to compare the anti-anemic efficacy of ASR-CDs with that of other therapeutic agents. A murine model of hematopoietic injury was established using cyclophosphamide and busulfan to investigate the effects of ASR-CDs on hematopoietic function. ASR-CDs displayed a nanoscale particle size range (1.444–4.006 nm) and surface groups including amino, carboxyl, and hydroxyl functionalities. Cellular assays involving RAW264.7 cells indicated no cytotoxicity, indicating favorable biosafety. In the zebrafish anemia model, ASR-CDs demonstrated superior efficacy in alleviating anemia compared to other tested agents. In mice, ASR-CDs significantly diminished chemotherapy-induced reduction in body weight, immune organ indices (liver, spleen, thymus), and peripheral blood cell counts (white blood cells, red blood cells, and platelets). Furthermore, ASR-CDs modulated hematopoiesis-related serum factors, with higher dosages producing more pronounced regulatory effects. ASR-CDs exerted a beneficial effect on chemotherapy-induced anemia. These results support the therapeutic potential of herbal-derived carbon dots and highlight the applicability of nanomaterials in pharmaceutical development.
Indexed as
Identifiers
40879842What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.