ArticlePharmacoEconomics2025
Developing an EQ-5D-5L Value Set for Singapore.
Article in PharmacoEconomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Economic Evaluation of a Digital Psychobehavioral Intervention for Chronic Inflammatory Skin Disease (MindMySkin): Protocol for a Trial-Based Cost-Effectiveness Analysis.JMIR research protocols · 2026Article
- Motor Imagery Brain-Computer Interface (MI-BCI)-Assisted Upper Limb Neurorehabilitation for Acute Stroke During Inpatient Rehabilitation: A Prospective Feasibility Study with Economic Evaluation Protocol.Journal of clinical medicine · 2026Article
- Article
- EQ-5D-5L population norms for Singapore: a household survey-based analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- An exploratory analysis of interaction effects in EQ-5D valuation using saturated EQ VAS datasets from the Netherlands, the United Kingdom, and China.Health and quality of life outcomes · 2026Article
- Factors associated with preoperative health-related quality of life in patients undergoing lumbar spine surgery: a multi-ethnic Asian cohort.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Independent associations between health-promoting behaviours, healthcare access, and health-related quality of life in Singapore.Scientific reports · 2026Article
- Elucidating the burden of dual-sensory impairment in community-based older individuals in a multi-ethnic society.Scientific reports · 2026Article
- Who Prefers Death to Life in Composite Time Trade-off Interviews, and Why? A Mixed-Methods Study among Asians in Singapore.The patient · 2026Article
- Article
- Health-related quality of life among multiethnic public polyclinic users in Singapore and associated factors: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Validation of the consumer health activation index (CHAI) among community-dwelling adults in primary care clinics in Singapore.Population health metrics · 2025Article
- Assessing patient preferences for medical decision making - a comparison of different methods.Frontiers in digital health · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesThe EQ-5D-5L is a multi-attribute utility instrument recommended by many health technology assessment agencies. This study aimed to develop an EQ-5D-5L value set for Singapore.
methodsA 'lite' version of the EuroQol Research Foundation's EQ-5D-5L valuation protocol, which was designed to value a total of 91 health states using a composite time trade-off (cTTO) method, was followed. Five hundred members of the general public in Singapore were quota-sampled and invited to a personal interview face-to-face or via Zoom. All participants completed 20 cTTO tasks administered using the EuroQol Valuation Technology (EQ-VT) program. Cross-validation analysis was performed to identify the best-performing model for estimating the values of all the 3,125 EQ-5D-5L health states.
resultsA 20-parameter main-effects model with two two-way interaction terms outperformed other models in the cross-validation analysis. The value set estimated using this model ranges from - 0.851 (for state 55555) to 1.000 (for state 11111), with pain/discomfort and anxiety/depression dimensions associated with the greatest disutility.
conclusionsWe developed an EQ-5D-5L value set based on the health preferences of Singaporeans. We recommend EQ-5D-5L users in Singapore to use this value set and encourage a more systematic and dedicated methodological effort to understand interaction effects and potential non-linearities in the valuation of multi-attribute health descriptive systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.