Evidence map›Paper›PMID 40880288›Full record

ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2025

Fibrosis 4 Index Predicts Haemocompatibility-Related Adverse Events in Patients Using Left Ventricular Assist Devices.

Takahiro Kurihara, Eisuke Amiya, Masaru Hatano, Junichi Ishida, Chie Bujo, Yoshitaka Isotani, Saki Kaneko, Satoru Ando, Kei Morishita, Satoshi Ishii and 9 more

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Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Takahiro KuriharaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Eisuke AmiyaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID 0000-0003-2810-8040
Masaru HatanoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Junichi IshidaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Chie BujoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Yoshitaka IsotaniDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Saki KanekoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Satoru AndoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Kei MorishitaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Satoshi IshiiDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Tomomi UedaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Hiroki YagiDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Akihito SaitoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Katsura SomaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Shun MinatsukiDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Masahiko AndoDepartment of Cardiovascular Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID 0000-0002-5481-3782
Shogo ShimadaDepartment of Cardiovascular Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Minoru OnoDepartment of Cardiovascular Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Norihiko TakedaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to explore the association between the liver fibrosis-4 (FIB4) index and clinical events, specifically haemocompatibility-related adverse events (HRAEs), in patients who underwent left ventricular assist device (LVAD) implantation.

methodsThe study involved patients who received LVADs for advanced heart failure (HF) treatment. FIB4 index was calculated both preoperatively and postoperatively, and its association with clinical events was examined, focusing on all-cause mortality and HRAEs, which included severe bleeding, cerebrovascular accidents, and intra-pump thrombosis.

resultsA total of 224 patients with LVAD were analyzed. The value of FIB4 index was significantly decreased after LVAD implantation, and the postoperative FIB4 index was independently associated with composite events, including all-cause death and HRAEs after adjustment of cofounders. Next, we clarified the association between postoperative FIB4 index and clinical events after LVAD implantation. Patients were divided into 2 groups based on a postoperative FIB4 index threshold of 1.45. The high FIB4 group was associated an elevated risk of HRAEs (P = 0.0038), with no significant difference in survival curves between the groups. Additionally, the high FIB4 group showed elevated von Willebrand factor activity, while no significant differences were found in prothrombin time international normalized ratio variability.

conclusionsFIB4 index, a liver fibrosis marker, serves as a valuable prognostic indicator for HRAEs in patients receiving LVAD support.

Indexed as

Heart-Assist DevicesHeart FailureLiver CirrhosisPostoperative ComplicationsAgedFemaleHumansMaleMiddle AgedRetrospective Studiesadvanced heart failurehaemocompatibility-related adverse eventleft ventricular assist deviceliver fibrosis index 4

Identifiers

PMID40880288
PMCPMC12448308

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.