Evidence map›Paper›PMID 40880478›Full record

ArticleScience advances2025

Excitotoxic neuronal death requires superoxide entry into neurons through volume-regulated anion channels.

Kate Harris, Seok Joon Won, Gokhan Uruk, Nguyen Mai, Devran Ogut, Yonghui Zhao, Litao Xie, Paul Baxter, Katharina Everaerts, Rajan Sah and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Special Issue "Mechanisms of Neurotoxicity".International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kate HarrisDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0005-4579-6393
Seok Joon WonDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8345-4037
Gokhan UrukDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8706-9443
Nguyen MaiDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4738-9733
Devran OgutNeurology Service, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.ORCID 0009-0004-3197-3945
Yonghui ZhaoCardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6192-4130
Litao XieCardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0001-4089-3830
Paul BaxterDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2142-1085
Katharina EveraertsDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0057-7147
Rajan SahCardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1092-1244
Raymond A SwansonDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3664-5359

Funding

NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)UE5NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Scott Andrew Josephson · 2024 to 2026
$2.6M
LRRC8 complex regulation of endothelial functionR01HL168600 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Rajan Sah · 2023 to 2026
$2.3M
Regulatory Control of Glutamate - Induced Superoxide Production [Admin Supplement]R01NS081149 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SWANSON, RAYMOND A · 2012 to 2016
$1.7M
SWELL1-LRRC8 mediated regulation of skeletal muscle function and metabolismR01DK127080 · NIDDK · WASHINGTON UNIVERSITY · PI SAH, RAJAN · 2021 to 2024
$1.7M
BLRD VA I01 BX004884BLRD VA I01 BX005072NHLBI NIH HHS R01 HL168600NIDDK NIH HHS R01 DK127080NINDS NIH HHS R01 NS081149NINDS NIH HHS UE5 NS070680
6 · The paper itself

Abstract

Neuronal death in stroke and other conditions stems in part from stimulation of

Indexed as

Ion ChannelsNeuronsSuperoxidesAnimalsCell DeathCells, CulturedCyclopentanesHumansIndansMembrane ProteinsMiceN-MethylaspartateOxidative StressReceptors, N-Methyl-D-Aspartate4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-one-5-yl)oxybutyric acidCyclopentanesIndansIon ChannelsLRRC8A protein, mouseMembrane ProteinsN-MethylaspartateReceptors, N-Methyl-D-AspartateSuperoxides

Identifiers

PMID40880478
PMCPMC12396328

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.