Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Rebecca M SouthernDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-1354-4635
Rebecca L SchmitzDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-5266-697X
Daniela Samaniego-CastruitaDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-6082-6603
Daniel BalsellsProgram on Inflammatory Diseases, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Discovery Institute, La Jolla, CA, USA.
Isabella HanDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.
Prathyaya RameshDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.
Mi Thao TranDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.ORCID 0009-0003-5556-1104
Carlos MontesDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.
Taek-Chin CheongDepartment of Pathology, Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0939-9412
Roberto ChiarleDepartment of Pathology, Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1564-8531
Ajay AbrahamDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-4094-2476
Ari WaismanInstitute for Molecular Medicine, University Medical Center (UMC), Mainz, Germany.ORCID 0000-0003-4304-8234
Robert C RickertProgram on Inflammatory Diseases, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Discovery Institute, La Jolla, CA, USA.
Vipul ShuklaDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-1422-5182
Ashima ShuklaDepartment of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-6943-5270
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
CARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4M
FUNCTION OF CD19 IN B CELL DEVELOPMENT/DIFFERENTIATIONR01AI041649 · NIAID · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI APGAR, JOHN R · 1998 to 2019
$7.0M
Antigen-specific B cell tolerance in the gut-associated lymphoid tissue (GALT)R01AI122344 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI APGAR, JOHN R · 2016 to 2020
$2.4M
APOBEC proteins as drivers of chromosomal translocations in solid cancersR01CA222598 · NCI · BOSTON CHILDREN'S HOSPITAL · PI CHIARLE, ROBERTO · 2018 to 2022
$2.0M
Regulation of germinal center homeostasis by the BAF complexR01AI187142 · NIAID · NORTHWESTERN UNIVERSITY · PI Vipul Shukla · 2025 to 2026
$1.2M
5-laser 30-parameter FACSymphony-S6 SORP Cell Sorter from BD BiosciencesS10OD026814 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERLMAN, HARRIS R · 2019 to 2019
$904k
Tumor suppressive functions of TET proteins in B cell malignancies: role of G-quadruplex structuresR00CA248835 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHUKLA, VIPUL · 2022 to 2024
$726k
FACSAria SORP Cell SorterS10OD011996 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOOLSBY, CHARLES L. · 2012 to 2012
Malignant B cells rely on B cell receptor (BCR) signals for their survival and growth. Besides the Immunoglobulin M (IgM) BCR, lymphoma cells can also express non-IgM (IgG) BCRs; however, the role of IgG BCRs in malignant B cell is not well understood. Here, we report poorer disease outcomes in diffuse large B cell lymphoma (DLBCL) expressing high IgM versus those expressing IgG1. Using isogenic lymphoma cells expressing distinct BCRs, we found that IgM expressing cells strongly outcompete their IgG1 counterparts. Mechanistically, IgG1 BCR is associated with a dysfunctional mitochondrial state and reduced cell survival. We show that mitochondrial dysfunction is triggered by accentuated calcium responses downstream of IgG1 BCR. Genetic reversal of IgG1 to IgM, pharmacological dampening of calcium signaling, or treatment with interleukin-21 can correct mitochondrial defects and rescue IgG1 survival. Our findings demonstrate that distinct BCR isotypes are inherently unique and can differentially affect B cell lymphoma pathogenesis.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.