Evidence map›Paper›PMID 40880488›Full record

ArticleScience advances2025

Shweta Singh, Kristbjorn O Gudmundsson, Tanmoy Sarkar, Brad L Jakubison, Holly M Morris, Sandra Burkett, Karim Baktiar, Gary T Pauly, Dina M Sigano, Joel P Schneider and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shweta SinghMouse Cancer Genetics Program, Center For Cancer Research, National Cancer Insitute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0001-9125-5727
Kristbjorn O GudmundssonMouse Cancer Genetics Program, Center For Cancer Research, National Cancer Insitute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0002-5995-2263
Tanmoy SarkarMouse Cancer Genetics Program, Center For Cancer Research, National Cancer Insitute-Frederick, NIH, Frederick, MD 21702, USA.
Brad L JakubisonMouse Cancer Genetics Program, Center For Cancer Research, National Cancer Insitute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0009-0001-0228-9392
Holly M MorrisMouse Cancer Genetics Program, Center For Cancer Research, National Cancer Insitute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0001-8979-8984
Sandra BurkettMouse Cancer Genetics Program, Center For Cancer Research, National Cancer Insitute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0002-5476-4028
Karim BaktiarMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0001-9604-9762
Gary T PaulyChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0002-3481-7129
Dina M SiganoChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0001-7489-9555
Joel P SchneiderChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD 21702, USA.
Lino TessarolloMouse Cancer Genetics Program, Center For Cancer Research, National Cancer Insitute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0001-6420-772X
Jonathan R KellerMouse Cancer Genetics Program, Center For Cancer Research, National Cancer Insitute-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0001-9767-0067

Funding

NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Hematopoietic malignancies emerge through the acquisition of genetic mutations within hematopoietic stem and progenitor cells (HSPCs). Some mutations impart a selective growth advantage to HSPCs, which expand and contribute to mature blood cells. This expansion is termed clonal hematopoiesis (CH). Inhibitor of DNA binding 1 (ID1) protein is a transcriptional regulator of proliferation/differentiation of hematopoietic cells. HSPCs express low levels of

Indexed as

Clonal HematopoiesisDNA-Binding ProteinsHematopoiesisInhibitor of Differentiation Protein 1Proto-Oncogene ProteinsAnimalsApoptosisCell ProliferationDioxygenasesHematopoietic Stem CellsMiceMice, KnockoutDioxygenasesDNA-Binding ProteinsIdb1 protein, mouseInhibitor of Differentiation Protein 1Proto-Oncogene ProteinsTet2 protein, mouse

Identifiers

PMID40880488
PMCPMC12396329

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.