Evidence map›Paper›PMID 40880768›Full record

ReviewFrontiers in medicine2025

Immunopathological syndromes: state of the art.

Dmitry Kudlay, Vladimir Kozlov, Andrey A Savchenko, Andrey Simbirtsev, Evgenia Anisimova, Igor Kudryavtsev, Anastasia Kulpina, Artem Rubinstein, Varvara A Ryabkova, Leonid P Churilov and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dmitry KudlayI.M. Sechenov First Moscow State Medical University, Institute of Pharmacy, Department of Pharmacology, Moscow, Russia.
Vladimir KozlovFederal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, Krasnoyarsk, Russia.
Andrey A SavchenkoFederal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, Krasnoyarsk, Russia.
Andrey SimbirtsevState Research Institute of Highly Pure Biopreparations, Saint Petersburg, Russia.
Evgenia AnisimovaState Research Institute of Highly Pure Biopreparations, Saint Petersburg, Russia.
Igor KudryavtsevInstitution of Experimental Medicine, Department of Immunology, St. Petersburg, Russia.
Anastasia KulpinaAlmazov National Medical Research Centre, Medical Department, Saint-Petersburg, Russia.
Artem RubinsteinInstitution of Experimental Medicine, Department of Immunology, St. Petersburg, Russia.
Varvara A RyabkovaSaint Petersburg State University, the Laboratory of the Mosaic of Autoimmunity, St. Petersburg, Russia.
Leonid P ChurilovSaint Petersburg State University, the Laboratory of the Mosaic of Autoimmunity, St. Petersburg, Russia.
Olga SirotkinaAlmazov National Medical Research Centre, Medical Department, Saint-Petersburg, Russia.
Tatyana VavilovaAlmazov National Medical Research Centre, Medical Department, Saint-Petersburg, Russia.
Anna An StarshinovaAlmazov National Medical Research Centre, Medical Department, Saint-Petersburg, Russia.
Alexandr BorisovFederal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, Krasnoyarsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The review of the current state of knowledge on local and systemic immunopathological reactions of cellular and humoral origin, as well as the ways of their interaction, is considered in this article. This study aimed to organize, standardize, and conceptualize existing knowledge about immunopathological syndromes associated with innate immunity. It highlights syndromes linked to type I, II, and III hypersensitivity reactions, while also separately examining manifestations related to immunosuppression disorders. The review outlines how to differentiate humoral immunity syndromes based on the classes of immunoglobulins A, M, E, and the four subclasses of immunoglobulin G. Additionally, it provides a detailed analysis of complement system disorders and the mechanisms of systemic inflammatory response syndrome, as well as their role in various pathological processes. The authors advocate for a unified set of definitions for immunopathological syndromes related to adaptive immunity, aiming to develop a new concept of their pathogenesis. Currently, many definitions of these syndromes lack consensus, stemming from varying interpretations of their manifestations. The authors also propose standardized tools for assessing immunopathological syndromes, along with guidelines for staging and treatment optimization.

Indexed as

adaptive immunityCOVID-19diagnostics of immune disordersimmune pathologyimmune systemimmunothrombosis

Identifiers

PMID40880768
PMCPMC12380852

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.