ArticleFrontiers in artificial intelligence2025
Population health management of human phenotype ontology.
Article in Frontiers in artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Population health management fit lifecycles in analytics.Frontiers in artificial intelligence · 2025Article
- Toward multiplex health: integrating complexity, normativity, and Open Science.Frontiers in psychology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Population Health Management (PHM), through strategic integration of the Human Phenotype Ontology (HPO), emphasises the responsible use of digital infrastructure and comprehensive genomic data to promote good health and wellbeing. The UK seeks to steward medical science and phenotype practices in primary care settings with technical approaches for developing a national Biological Modelling (BM) ecosystem. By recognising diverse global healthcare systems, this manuscript offers a means for nations to adapt their HPO operational deployment for global PHM harmony. Methods: The methodological approach incorporates primary care services and funding assessments to address digital infrastructure needs, ensuring secure national data access. Evaluations include ISO standards, systems thinking, alignment of UK infrastructure with informatics requirements, and AI norms within the ecosystem. Specific use cases for genomic predictive health pre-eXams and precise care eXams are assessed, alongside strategies for bias mitigation to ensure fairness in AI-driven classifications. Recommendations: The manuscript advocates for establishing local agile ecosystem groups for PHM, regional Higher Expert Medical Science Safety (HEMSS) stewardship, national HPO value-based care models, and integrating global PHM general intelligence. Real-world AI and clinical practice comparisons are emphasised for validating digital twin personalised BM via Gen AI in the HPO transformation ecosystem. Discussion: Federated Learning and GPT-5 technologies advance international PHM by supporting HPO transformations. Standard personalised BM learning addresses intranational HPO variances, requiring individual classifications. National HPO roadmaps prioritise inclusiveness and stakeholder engagement, supported by informed consent and quantum intelligence. Ethical and equitable HPO deployment demands proactive stewardship and national cooperation to address limitations and ensure robust classifications. Conclusion: Unified, data-driven HPO transformation utilising advanced AI and genomics is essential for personalised healthcare delivery. Rigorous assessments, ethical considerations, and global collaboration enable impactful implementation. National PHM ecosystems guided by HPO transformation in classifications sustain healthcare, advancing patient outcomes through responsible innovation and informed policy development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.