ArticleOrganometallics2025
CO Complexation by Ru(II) and Os(II) Porphyrin Complexes Sheds Light on the Relative Importance of Thermodynamic Stability and Kinetic Lability for CO Poisoning Antidotes.
Article in Organometallics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Despite the widespread occurrence of CO poisoning and the number of people left underserved by current treatment options, there are no clinically employed CO poisoning antidotes. Current efforts to develop candidate antidotes have focused on Fe-(II) complexes with a high binding affinity for CO, with small-molecule Fe-(II) porphyrin complexes demonstrating promising potential in this role. The well-established organometallic chemistry of group 8 metals suggests that Ru-(II) and Os-(II) analogs should be able to form even more stable carbonyl adducts than their Fe-(II) congeners. Here, we systematically investigate the impact of changing the group 8 metal on the ability of M-(II) complexes of 5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrinate (TPPS
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