Evidence map›Paper›PMID 40881066›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2025

Association of tailpipe-related and nontailpipe-related air pollution exposure with neuroimaging outcomes.

Ryan M Andrews, Stephanie T Grady, Neelum T Aggarwal, Todd L Beck, Klodian Dhana, Denis Evans, Pauline Maillard, Sarah Rothbard, Elizabeth A Stuart, Adam A Szpiro and 6 more

Abstract read
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ryan M AndrewsDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.ORCID https://orcid.org/0000-0002-7750-2397
Stephanie T GradyDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts.
Neelum T AggarwalDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.
Todd L BeckRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois.
Klodian DhanaRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois.
Denis EvansRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois.
Pauline MaillardImaging of Dementia and Aging Laboratory, Center for Neuroscience, Sacramento, California.
Sarah RothbardSlone Epidemiology Center, Boston University, Boston, Massachusetts.
Elizabeth A StuartDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Adam A SzpiroDepartment of Biostatistics, University of Washington, Seattle, Washington State.
Saarika VirkarDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Sara D AdarDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan.
Charles S DeCarliImaging of Dementia and Aging Laboratory, Center for Neuroscience, Sacramento, California.
Joel D KaufmanDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington State.
Kumar B RajanRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois.
Jennifer WeuveDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Risk Factors for Incident Alzheimer's Disease in a Biracial CommunityR01AG011101 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI EVANS, DENIS A · 1993 to 2010
$24.7M
Air pollution and noise exposures in relation to dementia: from brain imaging markers to clinical diseaseR01AG065359 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WEUVE, JENNIFER · 2020 to 2023
$2.3M
NIA NIH HHS R01 AG011101NIA NIH HHS R01 AG065359NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

Background: Long-term exposure to air pollution may be related to neural atrophy or cerebrovascular pathology. A major source of air pollution is vehicle traffic, which is modifiable. In this study, we estimated associations between four traffic-related air pollutants and five neuroimaging biomarkers. Methods: We analyzed data from a subset (N = 817) of participants in the Chicago Health and Aging Project (1993-2012) who underwent a structural magnetic resonance imaging (MRI) scan between 2002 and 2012. Using previously developed air pollution models, we predicted participant-level exposure to the tailpipe pollutants oxides of nitrogen (NO Results: Exposure to NO Conclusion: These results are not indicative of large adverse associations between traffic-related air pollution exposures and indicators of neural atrophy or cerebrovascular pathology.

Indexed as

Air PollutionAlzheimer’s disease pathologyMagnetic resonance imagingNeuroimaging

Identifiers

PMID40881066
PMCPMC12384963

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.