Evidence map›Paper›PMID 40881260›Full record

ArticleAmerican journal of lifestyle medicine2025

Assocation Between a Brain Care Score Derived from Participant Responses and Incident Stroke from the COSMOS Study.

Jasper R Senff, Reinier W P Tack, Benjamin Y Q Tan, Tamara N Kimball, Savvina Prapiadou, Devanshi Choksi, Tanzeela H Ranman, Taylor M McVeigh, Aladdin H Shadyab, H Bart Brouwers and 7 more

Abstract read
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In one paragraph

Article in American journal of lifestyle medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jasper R SenffBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).ORCID https://orcid.org/0009-0002-6540-480X
Reinier W P TackBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Benjamin Y Q TanBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Tamara N KimballBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Savvina PrapiadouBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Devanshi ChoksiBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Tanzeela H RanmanBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Taylor M McVeighBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science and Division of Geriatrics, Gerontology, and Palliative Care, Department of Medicine, University of California San Diego, La Jolla, CA, USA (AHS).
H Bart BrouwersDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands (JRS, RWPT, HBB, SDS).ORCID https://orcid.org/0000-0001-7044-8394
JoAnn E MansonDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (JEM, HDS, PMR).
Howard D SessoDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (JEM, HDS, PMR).
Christopher D AndersonBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Jonathan RosandBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Sanjula D SinghBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).
Pamela M RistDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (JEM, HDS, PMR).
Nirupama YechoorBrain Care Labs at Massachusetts General Brigham, Boston, MA, USA (JRS, RWPT, BYQT, TNK, SP, DC, THR, TMM, CDA, JR, SDS, NY).

Funding

WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00003 · NHLBI · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA · 2021 to 2025
$5.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2M
Cocoa Supplement and Multivitamin Outcomes Study in the Mind (COSMOS-Mind)R01AG050657 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BAKER, LAURA D., ESPELAND, MARK ANDREW · 2016 to 2020
$3.8M
Effect of randomized cocoa supplementation on inflammaging and epigenetic agingR01HL157665 · NHLBI · AUGUSTA UNIVERSITY · PI DONG, YANBIN, SESSO, HOWARD D · 2021 to 2024
$2.9M
COcoa Supplement and Multivitamins Outcomes Study (COSMOS): Effects on Falls and Physical PerformanceR01AG071611 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CRANDALL, CAROLYN JANET, LEBOFF, MERYL SUSAN · 2021 to 2024
$2.7M
COSMOS Eye: Cataract and AMD in a Trial of a Multivitamin and Cocoa ExtractR01EY025623 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI SESSO, HOWARD D · 2016 to 2020
$2.6M
NEI NIH HHS R01 EY025623NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS R01 HL157665NIA NIH HHS R01 AG050657NIA NIH HHS R01 AG071611Wellcome TrustWHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

objectiveThe Brain Care Score (BCS), previously validated to predict the risk of age-related brain diseases, incorporates 12 modifiable risk factors, including blood pressure and laboratory measurements. In the U.S., fewer than 50% of individuals recall these measurements, limiting the BCS's accessibility. This study aims to evaluate the predictive validity and discriminatory power of a BCS derived from participant responses for incident stroke.

methodsWe performed retrospective analyses using the prospectively collected COSMOS data. The BCS, ranging 0-19 points, was calculated from modifiable risk factors derived from participant responses only. A Cox proportional hazard model, adjusted for sex and age was used to estimate the association between a higher BCS, indicating better brain health, and incident stroke.

resultsAmong 17 150 participants (median age 70.8, 59.6% female) free of stroke and TIA at baseline and with complete BCS data, 187 (1.1%) experienced a stroke during a mean follow-up duration of 3.6 (SD:0.7) years. A 5-point higher BCS was associated with a 36% lower stroke risk (HR:0.64 [95%CI:0.48-0.84], c-statistic:0.68). DISCUSSION: A BCS derived from participant responses showed similar predictive performance and discriminatory ability compared to previous validation studies that use physical and laboratory measurements. Future studies could consider incorporating the BCS derived from participant responses when physical and laboratory measurements are not readily available.

Indexed as

accessibilitybrain care scorepreventionrisk factorsstroke

Identifiers

PMID40881260
PMCPMC12373657

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.