ArticleFrontiers in microbiology2025
Relieving effect of an Maren-Zhizhu emulsion on loperamide hydrochloride-induced constipation in mice and its effects on the gut microbiota.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Live and Heat-InactivatedNutrients · 2026Article
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9 authors.
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Abstract
Introduction: Constipation, a common gastrointestinal disorder, is rapidly increasing in prevalence worldwide. An increasing number of individuals are choosing traditional Chinese medicine (TCM) as an adjunctive treatment for constipation. In this study, the effect of Maren-Zhizhu emulsion (MRZZ) prepared with Methods: MRZZ was administered orally at low (0.65 g/kg) and high (2.6 g/kg) doses for 14 consecutive days. Loperamide hydrochloride (4 mg/kg) was used to induce constipation in male ICR mice. Colon tissue pathology, transcriptomics, and changes in the gut microbiota were analyzed to assess the efficacy of MRZZ in alleviating constipation. Results and discussion: We observed changes in fecal water content, time of first black stool, gastrointestinal transit rate, short-chain fatty acid (SCFAs) levels, and serum gastrointestinal regulatory peptide levels before and after consuming MRZZ. MRZZ increased the levels of relevant gastrointestinal regulatory neurotransmitters such as MTL, SP, and GAS, as well as SCFAs (especially acetate and isobutyrate). Furthermore, it reshaped the structure of the gut microbiota by increasing the relative abundance of
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