ArticleInternational journal of ophthalmology2025
Visual analysis of research trends in diabetes-associated dry eye
Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Corneal neuropathy: An overlooked biomarker for dry eye in type 2 diabetes.World journal of diabetes · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo provide a comprehensive review of the advances in research on diabetes-associated dry eye (DADE), highlighting its pathophysiological mechanisms, risk factors, and demographic characteristics, laying the foundation for further investigation into its pathogenesis and treatment strategies.
methodsA systemic review of the documents related to DADE had been performed based on the Web of Science database prior to achieving the plain text files of authors, titles, journals, and abstracts which afterwards had been imported into Citespace and VOSviewer software for data cleansing. The visual analysis was implemented from the following aspects: journals' publications, author and national cooperation, keyword co-occurrence, timeline analysis, and burst detection.
resultsThe 318 documents in 167 journals had been incorporated with the overall annual citations and annual publications respectively growing significantly since 2014 and 2016. The keyword co-occurrence networks formed 4 clusters, with the representative keywords being dry eye, diabetes mellitus, prevalence, and diabetic retinopathy. Both the timeline map and the burst detection demonstrated that in the exploration of the pathogenesis of DADE, initial research was dedicated to Sjögren's syndrome, followed by cross-sectional statistical analysis of the pertinent contributing factors of DADE using online databases. Precisely the oxidative stress seemed to surge into the research spotlight presently. The key pathogenic mechanisms of DADE include inflammation, oxidative stress and corneal neuropathy, contributing to the development of dry eye symptoms.
conclusionAge, gender, diabetes duration, and diabetic retinopathy are strongly associated with the development of DADE, but the impact of other systemic factors require further investigation. With high prevalence of dry eye in Asia, valuable resources like the Korea National Health and Nutrition Examination Survey (KNHANES) database offer crucial data for developing risk prediction models for DADE. Building risk prediction models using machine learning algorithms is a promising future research direction, enabling physicians to identify high-risk individuals and implement early interventions.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.