ReviewACS pharmacology & translational science2025
Recent Development of Boron-Containing Small-Molecule Anticancer Agents.
Review in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Goldilocks boronic esters: optimized properties through understanding hydrolysis kinetics.Chemical science · 2026Article
- Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Metal-Free Electrophilic Borylative Cyclizations of Alkynes.Chemical record (New York, N.Y.) · 2026Review
- Boron's Double Edge-Antibiotics, Toxins, and the Fine Line Between Them.Molecules (Basel, Switzerland) · 2026Review
- Boron-containing anticancer agents: a target-centric review of structure-activity relationships and clinical pipeline.Archives of pharmacal research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small-molecule anticancer agents containing boron have attracted growing attention due to their unique chemical properties and promising anticancer activities. This review systematically summarizes recent advances in developing boron-based small-molecule agents, highlighting their molecular structures, mechanisms of action, and therapeutic applications. Specifically, it covers key categories such as boron neutron capture therapy (BNCT) agents, boron-based enzyme inhibitors, novel benzoxaborole derivatives, and boron-based reactive oxygen species (ROS)-targeting agents. The challenges associated with these boron-containing drugs, including limited tumor selectivity, suboptimal boron accumulation, and low bioavailability, are also highlighted. Additionally, it offers perspectives on future directions in the field, providing insights intended to guide ongoing research and development in boron-based anticancer therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.