Evidence map›Paper›PMID 40881774›Full record

ArticleAdvanced functional materials2025

Glucose-Facilitated Nanomicelles Cross Peripheral Nerve Barriers to Achieve Drug Delivery to Nerves.

Xiaoyan Ma, Yuhao Cai, Sumiran Kumar Gurung, Shreyas S Rao, Chao Zhao

Abstract read
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoyan MaDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Yuhao CaiDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Sumiran Kumar GurungDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Shreyas S RaoDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA; Center for Convergent Biosciences and Medicine, University of Alabama, Tuscaloosa, AL 35487, USA.
Chao ZhaoDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA; Center for Convergent Biosciences and Medicine, University of Alabama, Tuscaloosa, AL 35487, USA.

Funding

Equipment Supplement - Cold triggered Local Anesthesia for Pain ManagementR01GM144388 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Chao Zhao · 2022 to 2026
$1.8M
Nanoparticles with Two-Stage Delivery of Tetrodotoxin for Prolonged Duration Local AnesthesiaR61NS123196 · NINDS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI ZHAO, CHAO · 2022 to 2023
$653k
Nanoparticles with Two-Stage Delivery of Tetrodotoxin for Prolonged Duration Local AnesthesiaR33NS123196 · NINDS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI ZHAO, CHAO · 2024 to 2024
$364k
NIGMS NIH HHS R01 GM144388NINDS NIH HHS R33 NS123196NINDS NIH HHS R61 NS123196
6 · The paper itself

Abstract

Injecting nerve-blocking agents near peripheral nerves is a clinical option for treating post-operative and chronic pain. However, the peripheral nerve barriers (PNBs) pose a physiological barrier that hinders the permeation of nerve-blocking agents through PNBs, ultimately affecting their efficacy on neurons. Here, glucose-modified nanomicelles (Glu-NMs) are developed that are self-assembled from glucose-functionalized 3-aminophenylboronic acid-polyethylene glycol- stearic acid polymer (GLU-PBA-PEG-SA) and Pluronic P

Indexed as

glucoseglucose transporternanomicellesperipheral nerve barriers

Identifiers

PMID40881774
PMCPMC12382365

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.