Evidence map›Paper›PMID 40881806›Full record

ArticleGMS hygiene and infection control2025

Hyperendemicity and genotype diversity of hepatitis B virus among patients attending the University of Abuja Teaching Hospital, Nigeria.

Chinwe Ndidi Ugwu, Amos Dangana, Hassan Suleiman Chunta, Ishaku Akyala Adamu, Nanpon Miri, Mangpin Leviticus Dansura, Bwede Eugene Samuel, Felix Villeng Gagari, Johnson Adeyemi Ojo, Nyiri Miriam Gyang and 5 more

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Article in GMS hygiene and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Chinwe Ndidi UgwuBiorepository Laboratory, Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria.
Amos DanganaNational Reference Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Hassan Suleiman ChuntaGlobal Health and Infectious Diseases Control Institute, Nasarawa State University, Keffi, Nigeria.
Ishaku Akyala AdamuGlobal Health and Infectious Diseases Control Institute, Nasarawa State University, Keffi, Nigeria.
Nanpon MiriNational Reference Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Mangpin Leviticus DansuraNational Reference Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Bwede Eugene SamuelNational Reference Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Felix Villeng GagariNational Reference Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Johnson Adeyemi OjoNational Reference Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Nyiri Miriam GyangMega Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Nkiruka Lynda UzoeboNational Reference Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Helen Daniel NanbolSchool of Medical Laboratory Science, Plateau State College of Health Technology, Pankshin, Nigeria.
Gabriel Bernice NyinishuSherrif Integrated Healthcare Limited, Abuja, Nigeria.
Aisha Daminso BardeMega Laboratory, Nigeria Center for Disease Control and Prevention, Abuja, Nigeria.
Idris Nasir AbdullahiDepartment of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatitis B virus (HBV) infection remains a significant global public health issue, particularly in sub-Saharan Africa, due to inadequate healthcare and research into its genetic epidemiology. This study aims to determine the frequency of HBV antigens, antibodies, and genotypes among febrile patients attending the University of Abuja Teaching Hospital (UATH), Nigeria. Methods: This cross-sectional study enrolled 100 patients, whose blood samples were collected and screened for HBV surface antigen (HBsAg) and four other structural antigens and antibodies by Lateral Flow Assay. All HBsAg-positive samples were genotyped using type-specific polymerase chain reactions. Structured questionnaires were used to collate the sociodemographic variables of the patients. Results: HBsAg-seropositivity was 31%. The distribution of HBV genotypes was as follows: genotype E was predominant (22.6%), followed by genotype B (16.1%). Of the HBsAg-positive individuals, all were HBsAb-seronegative, 3.2%, 74.2%, and 90.3% were HBeAg, HbeAb, and HBcAb seropositive, respectively. Genotypes B, C, and D were detected in 16.1%, 3.2%, and 3.2%, respectively. Based on the number of HBV genotypes per individual, 9.7% had a single genotype, 16.1% had double genotypes, and 74.2% had triple genotypes. Higher educational qualification was significantly associated with triple HBV genotypes per individual ( Conclusion: Very high seroprevalence of HBV was found and genotype E predominated. The presence of within-host multiple HBV genotypes was identified for the first time in Nigeria. This indicates the genetic heterogeneity of HBV in northern Nigeria and suggests potential effects on the control measures available.

Indexed as

endemicityHBsAgHBV genotypeNigeria

Identifiers

PMID40881806
PMCPMC12381866

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