ArticleNPJ Parkinson's disease2025
Chronic adaptive deep brain stimulation for Parkinson's disease: clinical outcomes and programming strategies.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- The Place of Adaptive Deep Brain Stimulation in Parkinson's Disease: Spatial before Temporal Optimization.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.Nature medicine · 2026Article
- Adaptive deep brain stimulation in Parkinson disease: clinical implementation and outlook.Nature reviews. Neurology · 2026Article
- Behavioral changes preceded by subthalamic nucleus activity alterations in a progressive macaque model of Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states.bioRxiv : the preprint server for biology · 2026Article
- Lactate dynamics in Parkinson's disease: striatal circuit vulnerability, biomarker potential, and therapeutic windows.Molecular medicine (Cambridge, Mass.) · 2026Review
- DBSsync: combining intracranial and multimodal data to investigate new biomarkers in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Dynamic neural states underpin motor symptom severity in Parkinson's disease: a longitudinal analysis of chronic cortico-subthalamic nucleus recordings.EBioMedicine · 2026Article
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Real-Time ECG Artifact Removal for Adaptive Deep Brain Stimulation: A Comparative Study.Sensors (Basel, Switzerland) · 2026Article
- Cognitive trajectories in Parkinson's disease patients, a review on the impact of subthalamic deep brain stimulation (STN-DBS) and emerging adaptive strategies.Translational psychiatry · 2026Review
- Chronic adaptive deep brain stimulation in Parkinson's disease: ADAPT-START findings and programming principles.NPJ Parkinson's disease · 2026Article
- Decoding the impact of visual states on adaptive deep brain stimulation feedback signals in movement disorders.NPJ Parkinson's disease · 2026Article
- Proceedings of the 13th annual deep brain stimulation think tank: the evolving landscape.Frontiers in human neuroscience · 2026Review
- Advances in deep brain stimulation for movement disorders.Annals of medicine and surgery (2012) · 2026Article
- The Modern Utility of Awake Deep Brain Stimulation Surgery.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Adaptive deep brain stimulation (DBS) dynamically adjusts stimulation amplitude based on neurophysiological feedback and may alleviate residual motor fluctuations in patients with Parkinson's disease. However, potential clinical benefits and programming strategies remain poorly understood. We programmed eight patients with Parkinson's disease on commercially available Dual Threshold adaptive DBS based on subthalamic beta power. Symptom severity was evaluated at home using ecological momentary assessments during two weeks of both continuous and adaptive DBS. Patients were not blinded to the stimulation mode. On the group level, overall well-being significantly improved with adaptive DBS (p = 0.007), and there was a non-significant trend toward enhanced general movement (p = 0.058). Within-subject analysis showed a significant improvement in overall well-being and general movement in three of eight patients. Six of eight patients chose to remain on adaptive DBS. Programming challenges included biomarker selection, threshold definition, and artifact-related maladaptation, for which targeted strategies are reported. Our findings support adaptive DBS as a potential option for selected Parkinson's disease patients with persistent motor symptoms on continuous DBS. We propose a three-step programming approach to guide clinical implementation of adaptive DBS.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.