Evidence map›Paper›PMID 40883428›Full record

ArticleScientific reports2025

Reduced field-of-view DWI outperforms conventional DWI in assessing tumor heterogeneity and HPV status in head and neck cancer.

Marta D Switlyk, Einar Dale, Svetlana Tafjord, Lise Willumsen, Knut H Hole, Tord Hompland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marta D SwitlykDepartment of Radiology, The Norwegian Radium Hospital, Oslo University Hospital, Nydalen, 4953, Oslo, Norway. marta.switlyk@ous-hf.no.
Einar DaleDepartment of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Svetlana TafjordDepartment of Pathology, Oslo University Hospital, Oslo, Norway.
Lise WillumsenDepartment of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Knut H HoleDepartment of Radiology, The Norwegian Radium Hospital, Oslo University Hospital, Nydalen, 4953, Oslo, Norway.
Tord HomplandDepartment of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reduced field-of-view diffusion-weighted imaging (reduced-FOV DWI) is a promising technique for assessing tumor heterogeneity and microstructure. In this study, we evaluated the ability of reduced-FOV DWI to identify specific patterns associated with human papillomavirus (HPV) exposure in head and neck squamous cell carcinoma (HNSCC). Whole-lesion analysis of the tumor was performed on reduced-FOV and conventional DWI using a multi b value sequence. The extracted parameters included the 10th-90th percentile of the apparent diffusion coefficient (ADC) and fractional blood volume (fBV), skewness, and kurtosis. The differences between HPV-negative and HPV-positive tumors were greater for reduced-FOV DWI. ADC was significantly lower in HPV-positive tumors (reduced-FOV DWI: p < 0.001, r

Indexed as

Diffusion Magnetic Resonance ImagingHead and Neck NeoplasmsPapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckAdultAgedFemaleHumansMaleMiddle AgedPapillomaviridaeDWIHNSCCHPVMRI

Identifiers

PMID40883428
PMCPMC12397206

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.