ReviewPharmacology research & perspectives2025
The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases.
Review in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Andrographolide: Mechanisms and Therapeutic Potential in Alzheimer's and Parkinson's Disease.Molecules (Basel, Switzerland) · 2026Review
- Portable, Rapid, and Cost-Effective Smartphone-Based Colorimetric Quantification of Total Lactones inPharmaceuticals (Basel, Switzerland) · 2026Article
- Screening-based repurposing identifies potassium dehydroandrographolide succinate (KDAS) as a selective suppressor of TNF-α-induced caspase-8-dependent apoptosis in colonic epithelial cells.Scientific reports · 2026Article
- Metabolic Reprogramming by Andrographolide: Enhanced Pentose Phosphate Pathway and Antioxidant Capacity in Cortical Astrocytes.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Multi-Target Anti-Steatotic Effects of Andrographolide in MAFLD: Insights from Network Pharmacology and in vitro Study.Journal of experimental pharmacology · 2026Article
- Andrographolide inhibits STAT1 expression and desensitizes interferon γ-induced priming in macrophage cells.Frontiers in pharmacology · 2026Article
- Andrographolide and Its Derivatives: A Comprehensive Review of Anti-Infective Properties and Clinical Potential.Molecules (Basel, Switzerland) · 2025Review
- The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases.Pharmacology research & perspectives · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Andrographolide, a diterpenoid component found in traditional Chinese medicine Andrographis paniculata, is known as a natural antibiotic and can be used to treat inflammatory lesions of various systemic diseases. In recent years, andrographolide derivatives have been continuously synthesized and have shown good anti-inflammatory pharmacological activity. These derivatives are mainly obtained by chemical synthesis methods, for example, by altering the hydroxyl and double bond groups in the molecule of andrographolide and introducing different substituents, thus obtaining derivatives with different biological activities and pharmacological properties. This paper summarizes the anti-inflammatory mechanism of andrographolide derivatives and the progress of pharmacological research in inflammatory diseases, such as viral infectious diseases, respiratory or lung injury, gastrointestinal diseases, liver injury, and neurological disorders. It also incorporates the results of our own team's research to deeply explore their therapeutic potential in different inflammatory diseases, which provides direction and rationale for in-depth follow-up research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.