ArticleMethods in molecular biology (Clifton, N.J.)2025
Transcription-Replication Conflicts and Incomplete Replication as a Cause of Micronuclei-Driven Chromoanagenesis.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Polymerase face-off: emerging concepts in transcription-replication coordination.EMBO reports · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancers are characterized with altered genomes. Sequencing of thousands of cancer genomes has led to the identification of new types of complex genomic rearrangements that generate new chromosomes, known as chromoanagenesis. Chromothripsis is, to-date, the best characterized phenomenon of complex rearrangements, in which a single chromosome pulverization is followed by reassembly of broken DNA fragments in a random manner. Chromothripsis and chromothripsis-related events predominantly stem from mitotic- and post-mitotic aberrations, notably in consequence of chromatin bridges and micronuclei breakage. These mitotic defects result either from DNA breaks or from perturbations in the DNA replication program, leading to under-replication and DNA damage. In this chapter we describe the molecular mechanisms that connect replication stress to chromothripsis-related events. We focus on transcription-replication conflicts as a major source of endogenous replication stress.
Indexed as
Identifiers
40884659What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.