ReviewCell reports2025
The bidirectional interplay between RNA processing and mechanotransduction.
Review in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Article
- Targeting the Calcineurin Homologous Protein 1 (CHP1)-Transmembrane Protein 87A (TMEM87A) mechanosensing complex: a druggable vulnerability in metastatic ovarian cancer.Molecular biomedicine · 2026Article
- Piezo channels in tumors.Journal of cancer research and clinical oncology · 2026Review
- Forces that shape the transcriptome: Linking cellular mechanosensing to mRNA splicing.The Journal of biological chemistry · 2026Review
- Nuclear Mechanics and Nuclear Mechanotransduction in Cancer Cell Migration and Invasion.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Through mechanotransduction, cells sense and respond to mechanical stimuli from their environment. A mechanical stimulus is first detected by a mechanosensor, then converted into a biochemical signal, which can ultimately control the expression of genes. RNA processing, which includes canonical and alternative splicing, 3' end polyadenylation, and 5' end capping, is a mechanism that fine-tunes gene expression regulation. Here, we provide an overview of recent studies revealing substantial links between mechanotransduction and RNA processing, with a focus on alternative splicing and polyadenylation. We first describe the molecular players that are known to mediate mechanotransduction. Then, we examine how mechanical forces inform the functions of RNA-binding proteins. We next summarize recent investigations demonstrating that genes encoding mechanosensory proteins are alternatively spliced and how alternative splicing might impact isoform functions. Last, we discuss the role of mechanical forces on alternative splicing and polyadenylation landscapes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.