Evidence map›Paper›PMID 40885186›Full record

ArticleCell reports2025

Amyloid-β-driven Alzheimer's disease reshapes the colonic immune system in mice.

Priya Makhijani, Taylor R Valentino, Max Manwaring-Mueller, Rohini Emani, Wei-Chieh Mu, Carlos Galicia Aguirre, Christopher Ryan Tan, Anand Rane, Kenneth A Wilson, Alexander Kifle and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Priya MakhijaniDepartment of Immunology, University of Toronto, Toronto, ON, Canada; Buck Institute for Research in Aging, Novato, CA, USA.
Taylor R ValentinoBuck Institute for Research in Aging, Novato, CA, USA.
Max Manwaring-MuellerBuck Institute for Research in Aging, Novato, CA, USA.
Rohini EmaniBuck Institute for Research in Aging, Novato, CA, USA.
Wei-Chieh MuBuck Institute for Research in Aging, Novato, CA, USA; Buck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, USA.
Carlos Galicia AguirreBuck Institute for Research in Aging, Novato, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Christopher Ryan TanDepartment of Immunology, University of Toronto, Toronto, ON, Canada; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Anand RaneBuck Institute for Research in Aging, Novato, CA, USA.
Kenneth A WilsonBuck Institute for Research in Aging, Novato, CA, USA.
Alexander KifleBuck Institute for Research in Aging, Novato, CA, USA.
Nan ChenDivision of Cellular & Molecular Biology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.
Huixun DuBuck Institute for Research in Aging, Novato, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Fei WuBuck Institute for Research in Aging, Novato, CA, USA; Buck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, USA.
Jenny Hong Yu NgBuck Institute for Research in Aging, Novato, CA, USA.
Benjamin D AmbroseBuck Institute for Research in Aging, Novato, CA, USA.
Prasanna Vadhana Ashok KumaarBuck Institute for Research in Aging, Novato, CA, USA.
Saad KhanDepartment of Immunology, University of Toronto, Toronto, ON, Canada; Division of Cellular & Molecular Biology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Shawn WinerDepartment of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.
Chao WangDepartment of Immunology, University of Toronto, Toronto, ON, Canada; Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada.
Arthur MorthaDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
David FurmanBuck Institute for Research in Aging, Novato, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Buck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, USA; Stanford 1,000 Immunomes Project, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
Birgit SchillingBuck Institute for Research in Aging, Novato, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Lisa M EllerbyBuck Institute for Research in Aging, Novato, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Olga L RojasDepartment of Immunology, University of Toronto, Toronto, ON, Canada; Krembil Brain Institute, University Health Network, Toronto, ON, Canada. Electronic address: olga.rojas@uhn.ca.
Julie K AndersenBuck Institute for Research in Aging, Novato, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. Electronic address: jandersen@buckinstitute.org.
Daniel A WinerDepartment of Immunology, University of Toronto, Toronto, ON, Canada; Buck Institute for Research in Aging, Novato, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Division of Cellular & Molecular Biology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address: dwiner@buckinstitute.org.

Funding

Single cell analysis coreP01AG066591 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI MELOV, SIMON · 2021 to 2025
$15.5M
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
New mechanistic insights into how the gut metabolite urolithin A extends lifespan and prevents ADRF1AG062280 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI ANDERSEN, JULIE KAY · 2018 to 2022
$3.9M
The B Cell Insulin Receptor in Health and in Insulin ResistanceR01DK128435 · NIDDK · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Dan Winer · 2022 to 2026
$2.9M
NIA NIH HHS P01 AG066591NIA NIH HHS RF1 AG062280NIA NIH HHS T32 AG000266NIDDK NIH HHS R01 DK128435
6 · The paper itself

Abstract

The "gut-brain axis" is an emerging target in Alzheimer's disease (AD), although its immunological features remain poorly understood. Using single-cell RNA sequencing, coupled to extensive spectral-tuning flow cytometry validation of the colon immune compartment in the 5XFAD amyloid-β mouse model, we found several AD-associated changes including in B/plasma cell activity. Notably, levels of CXCR4

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesColonAnimalsB-LymphocytesBrainDisease Models, AnimalGastrointestinal MicrobiomeHumansImmunoglobulin AMaleMiceMice, TransgenicReceptors, CXCR4Amyloid beta-PeptidesImmunoglobulin AReceptors, CXCR4Alzheimer’s diseaseB cellschemokine axisCP: ImmunologyCP: NeuroscienceCXCR4dietary interventiongut-brain axisimmunometabolismmucosal immunityneuroimmunologyplasma cells

Identifiers

PMID40885186
PMCPMC12520713

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.