Evidence map›Paper›PMID 40885730›Full record

ArticleScientific reports2025

Mesenchymal stem cells suppress NF-κB and ERK signalling while enhancing chemotaxis in CD4

Ezgi Sengun, Janeri Fröberg, Xuehui He, Marc Eleveld, Ruben L Smeets, Hans J P M Koenen, Katja Möller-Hackbarth, Tim G A M Wolfs, Daan R M G Ophelders, Martijn A Huynen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ezgi SengunDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Route 469, Geert Grooteplein 10, PO-Box 9101, 6500 HB, Nijmegen, The Netherlands. ezgi.sengun@radboudumc.nl.
Janeri FröbergDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Route 469, Geert Grooteplein 10, PO-Box 9101, 6500 HB, Nijmegen, The Netherlands.
Xuehui HeDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Route 469, Geert Grooteplein 10, PO-Box 9101, 6500 HB, Nijmegen, The Netherlands.
Marc EleveldDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Route 469, Geert Grooteplein 10, PO-Box 9101, 6500 HB, Nijmegen, The Netherlands.
Ruben L Smeets *Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Route 469, Geert Grooteplein 10, PO-Box 9101, 6500 HB, Nijmegen, The Netherlands.
Hans J P M Koenen *Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Route 469, Geert Grooteplein 10, PO-Box 9101, 6500 HB, Nijmegen, The Netherlands.
Katja Möller-HackbarthGlobal Rare Disease, Chiesi Pharma AB, 17165, Solna, Sweden.
Tim G A M WolfsDepartment of Paediatrics, MosaKids Children's Hospital, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Daan R M G OpheldersDepartment of Paediatrics, MosaKids Children's Hospital, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Martijn A Huynen *Center for Molecular and Biomolecular Informatics, Radboud University Medical Centre Nijmegen, Radboud University for Molecular Life Sciences, Nijmegen, 6525 GA, The Netherlands.
Marien I de Jonge *Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Route 469, Geert Grooteplein 10, PO-Box 9101, 6500 HB, Nijmegen, The Netherlands.
Renate G van der MolenDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Centre Nijmegen, Radboud Institute for Molecular Life Sciences, Route 469, Geert Grooteplein 10, PO-Box 9101, 6500 HB, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is regulated by immune cells, with CD4

Indexed as

CD4-Positive T-LymphocytesChemotaxisMAP Kinase Signaling SystemMesenchymal Stem CellsNF-kappa BCell AdhesionCell MovementCells, CulturedDNA-Binding ProteinsGene Expression RegulationHumansImmunologic MemoryImmunomodulationLymphocyte ActivationDNA-Binding ProteinsNF-kappa BTNIP1 protein, humanCD4 + TERKImmunomodulationMemoryMigrationNF-κBSignallingUC-MSCs

Identifiers

PMID40885730
PMCPMC12398613

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.