Evidence map›Paper›PMID 40885749›Full record

ArticleScientific reports2025

Individual and combined effects of ischemic conditioning strategies on infarct size after myocardial ischemia reperfusion.

Ahmed Elmahdy, Maryna Krasnikova, Abhishek Jha, Tetiana Pylova, Aaron Shekka Espinosa, Ermir Zulfaj, Erik Axel Andersson, Mana Kalani, Aditi Banerjee, Ola Hammarsten and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ahmed ElmahdyDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden. ahmed.elmahdy@wlab.gu.se.
Maryna KrasnikovaDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.
Abhishek JhaDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.
Tetiana PylovaDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.
Aaron Shekka EspinosaDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.
Ermir ZulfajDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.
Erik Axel AnderssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.
Mana KalaniDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.
Aditi BanerjeeDepartment of Clinical Chemistry, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Ola HammarstenDepartment of Clinical Chemistry, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Elmir OmerovicDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.
Björn RedforsDepartment of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Blå stråket 5 B Wallenbergslab/SU, 413 45, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic preconditioning (PreC), remote perconditioning (PerC), and postconditioning (PostC) are known to reduce myocardial infarct size, but their relative efficacy and potential additive effects remain unclear. This study compared the individual and combined effects of PreC, PerC, and PostC on infarct size and cardiac troponin I (cTnI) levels in a rat model of myocardial ischemia-reperfusion. Fifty-four male Sprague-Dawley rats underwent 40 min of coronary occlusion followed by 2 h of reperfusion. They were randomized into six groups: Control, PreC, PerC, PostC, PerC + PostC, or PreC + PerC + PostC. Infarct size was measured using Evans blue/TTC staining, and cTnI levels were assessed. All conditioning strategies significantly reduced infarct size and cTnI levels compared to control (p < 0.001). PreC and PreC + PerC + PostC were the most effective, while PostC was the least. No additive benefit was seen when combining PreC with other strategies (p = 0.9) or PerC with PostC (p = 0.9). These findings suggest that PreC provides the greatest cardioprotection, and combining conditioning strategies does not enhance outcomes, possibly due to overlapping protective mechanisms.

Indexed as

Ischemic PostconditioningIschemic Preconditioning, MyocardialMyocardial InfarctionMyocardial Reperfusion InjuryAnimalsDisease Models, AnimalMaleMyocardiumRatsRats, Sprague-DawleyTroponin ITroponin IIschemic postconditioningIschemic preconditioningIschemic remote perconditioningMyocardial infarctionTroponin I

Identifiers

PMID40885749
PMCPMC12398535

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.