ArticleCommunications biology2025
Fronto-motor circuits linked to effort-based decision-making and apathy in healthy subjects.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of glucagon-like peptide-1 receptor agonists on objective physical activity in adults: a systematic review and exploratory meta-analysis.International journal of obesity (2005) · 2026Pooled it
- Subthalamic nucleus deep brain stimulation connectivity related to apathy outcomes in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Apathy is marked by disruptions in effort-based decision-making for rewards and alterations in fronto-basal ganglia (BG) circuits. While changes in primary motor cortex (M1) activity during effort and reward valuation have been reported, prior work on apathy and effort-based decision-making has overlooked the connections between fronto-BG structures and M1. Here, we addressed this gap by investigating structural and effective connectivity within fronto-M1, fronto-BG-M1, and intra-M1 circuits in 45 healthy participants using tractography and paired-pulse transcranial magnetic stimulation. These measures were related to apathy scores and computational parameters of effort and reward valuation modelled from decision-making behavior. Apathy scores were associated with both structural and effective connectivity in orbitofrontal cortex-originating circuits. Additionally, effort and reward valuation were preferentially linked to supplementary motor area-related circuits and intra-M1 GABAergic circuits, respectively. These findings reveal dissociable circuit-level contributions to different dimensions of motivated behavior and identify potential neuromodulation targets for treating apathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.