SynthesisActa diabetologica2025
Serum lipids changes following cocoa intake in type 2 diabetes patients: a graded dose-response systematic review and meta-analysis of clinical trials.
Synthesis in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
introductionHyperlipidemia, a prevalent comorbidity among type 2 diabetes patients, is a potential risk factor for cardiovascular diseases. It is unclear whether cocoa has beneficial impacts on the serum lipids of patients with diabetes.
methodsPubMed, Scopus, and Embase databases were systematically reviewed for clinical trials on cocoa intake and blood lipids in type 2 diabetes until January 1, 2024, and the reference list of relevant articles was searched manually. Two reviewers extracted data and determined the risk of bias (RoB) using the Cochrane tool. The random effect model was applied to calculate standardized mean differences (SMDs). Finally, the certainty and clinical importance of the evidence were checked (PROSPERO registration code: CRD42021224931).
resultEleven RCTs with 506 participants were included. Different forms of cocoa and various intervention durations were applied. Only two RCTs had a low RoB. Findings showed a significant reduction in serum triglyceride (SMD: - 0.57, 95% CI - 1.05, - 0.10, I
conclusionAlthough cocoa may slightly change serum lipids in diabetes, its recommendation for lipids control has fair clinical benefits. Due to the lack of certainty of findings and an inadequate number of studies, further well-designed trials considering possible sources of heterogeneity with low RoB are highly recommended.
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40886195What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.