ArticleAging clinical and experimental research2025
Impact of high body fat and low muscle mass on bone mineral density in postmenopausal women with type 2 diabetes: A DXA-based cross-sectional study.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Association of handgrip strength and CT-derived body composition with insulin resistance in women with prediabetes and newly diagnosed type 2 diabetes.Archives of endocrinology and metabolism · 2026Article
- Overview of research and practice progress in body composition measurement techniques.Frontiers in medical technology · 2026Review
- Moving beyond association: the imperative for mechanistic and longitudinal research on body composition and bone quality in diabetic osteopathy.Aging clinical and experimental research · 2025Article
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Abstract
BACKGROUND AND
objectiveSarcopenic obesity, defined as the coexistence of reduced muscle mass and excess adiposity, may adversely affect bone health, especially in postmenopausal women with type 2 diabetes mellitus (T2DM). This study aimed to explore the association between different body composition phenotypes, particularly sarcopenic obesity, and bone mineral density (BMD) in this population.
methodsWe retrospectively analyzed 573 postmenopausal women with T2DM hospitalized between September 2020 and October 2024. Based on appendicular skeletal muscle mass index (ASMI) and body fat percentage (BFP) measured by dual-energy X-ray absorptiometry (DXA), participants were classified into control, obesity alone, sarcopenia alone, and sarcopenic obesity groups. Associations between phenotypes and BMD were assessed using Spearman correlation, logistic regression, and restricted cubic spline (RCS) models.
resultsThe obesity group had the highest BMD, while the sarcopenia group had the lowest. Sarcopenic obesity was associated with significantly lower lumbar spine and hip BMD and a higher risk of osteoporosis. Obesity showed a protective effect (OR = 0.515, P = 0.002), whereas sarcopenic obesity increased osteoporosis risk (OR = 3.368, P = 0.007). RCS analysis revealed nonlinear relationships between ASMI, BFP, and BMD.
conclusionSarcopenic obesity significantly increases osteoporosis risk in postmenopausal women with T2DM, while isolated obesity may protect bone mass. Routine body composition assessment is essential for early identification and targeted intervention.
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