Evidence map›Paper›PMID 40886253›Full record

ArticleUpdates in surgery2026

Necessity of systematic lymph node dissection in early-stage pure solid lung cancer adjacent to the mediastinum.

Wen-Yuan Lu, Zhi-Chang Yang, Zhi-Yuan Chen, Yang Zhao, Xiao-Ming Chen, Ji-Ze Wu, Yang Yang

Abstract read
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In one paragraph

Article in Updates in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen-Yuan Lu *Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshedong Rd, Zhengzhou, 450000, People's Republic of China.
Zhi-Chang Yang *Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshedong Rd, Zhengzhou, 450000, People's Republic of China.
Zhi-Yuan ChenDepartment of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshedong Rd, Zhengzhou, 450000, People's Republic of China.
Yang ZhaoDepartment of Thoracic Surgery, Anyang Tumor Hospital, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang, China.
Xiao-Ming ChenDepartment of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshedong Rd, Zhengzhou, 450000, People's Republic of China.
Ji-Ze WuDepartment of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshedong Rd, Zhengzhou, 450000, People's Republic of China.
Yang YangDepartment of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshedong Rd, Zhengzhou, 450000, People's Republic of China. yangyang_2046@126.com.

Funding

the Leading Talent Cultivation Project of Henan Health Science and Technology Innovation Talents YXKC2021016
6 · The paper itself

Abstract

Pure solid lung cancer is associated with higher lymph node metastasis rates, therefore identifying the risk factors and metastatic patterns of lymph node involvement in early-stage pure solid lung cancer is a critical research topic. We retrospectively collected preoperative Computed Tomography (CT) imaging and postoperative pathological data of patients with pure solid lung cancer from 2021 to 2025 to investigate the risk factors and patterns of lymph node metastasis. Among 8718 patients, 104 with ≤ 2 cm pure solid lung cancer were analyzed, with a lymph node metastasis rate of 20.19% (21/104). Risk factors included mediastinal proximity (Odds Ratio (OR) = 11.83, 95% CI 2.18-64.32, p = 0.004) and ALK-positivity (OR = 15.13, 95% CI 1.68-136.01, p = 0.015). In 76 clinical stage IA patients, the metastasis rate was 15.79% (12/76). Risk factors were mediastinal proximity (OR = 11.53, 95% CI 1.13-118.01, p = 0.039), and ALK-positivity (OR = 33.74, 95% CI 3.02-376.65, p = 0.004). Upper lobe pure solid lung cancers tended to metastasize to the superior mediastinal lymph nodes (p = 0.011). Mediastinal proximity and ALK-positivity were independent risk factor of lymph node metastasis in pure solid lung cancer. Systematic lymph node dissection is proper for mediastinal-adjacent pure solid lung cancer.

Indexed as

Lung NeoplasmsLymph Node ExcisionMediastinumAdultAgedFemaleHumansLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm StagingRetrospective StudiesRisk FactorsTomography, X-Ray ComputedLymphatic metastasisLymph node excisionPure solid lung cancerTumour location

Identifiers

PMID40886253

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.