Evidence map›Paper›PMID 40886274›Full record

ReviewAdvances in experimental medicine and biology2025

The Internal Ribosome Entry Site in Circular RNAs.

Queenie Fernandes, Zeenath Safira K M Yoosuf, Sarra Mestiri, Laila Assami, Karama Makni-Maalej, Shahab Uddin, Maysaloun Merhi, Said Dermime

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Queenie FernandesTranslational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Zeenath Safira K M YoosufTranslational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Sarra MestiriTranslational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Laila AssamiTranslational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Karama Makni-MaalejTranslational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Shahab UddinTranslational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
Maysaloun MerhiTranslational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Said DermimeTranslational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar. sdermime@hamad.qa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The internal ribosome entry site (IRES) within circular RNAs (circRNAs) has emerged as a dynamic and multifaceted regulatory element, challenging traditional notions of translation initiation in eukaryotic cells. This chapter reviews the current state of research and knowledge on IRES in circRNAs, exploring its molecular mechanisms, physiological roles, and therapeutic implications. As the field continues to evolve, research efforts are essential for a comprehensive understanding of the interplay between IRES and circRNAs. This work also highlights the future directions in the study of IRES within circRNAs, underscoring its significance in gene expression regulation and opening new avenues for therapeutic innovation.

Indexed as

Internal Ribosome Entry SitesRibosomesRNARNA, CircularAnimalsGene Expression RegulationHumansProtein BiosynthesisInternal Ribosome Entry SitesRNARNA, CircularCap-independent translationCircular RNA (circRNA)Internal Ribosome Entry Site (IRES)IRES trans-acting factors (ITAFs)Non-canonical translation;RNA translation mechanisms

Identifiers

PMID40886274

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.