ReviewAdvances in experimental medicine and biology2025
Circular RNAs in Liver Diseases.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs), a class of recently discovered noncoding RNAs, exhibit a distinctive feature in comparison to other noncoding RNAs, such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). They are characterized by the formation of a covalent bond between the 3' and 5' ends through a process known as back-splicing, rendering them remarkably resistant to degradation by exonucleases, particularly RNase R. This inherent stability contributes to their prolonged expression compared to their linear counterparts. Recent investigations have unveiled the pivotal role of circRNAs in the regulation of gene expression through various mechanisms, including the modulation of host gene splicing, acting as miRNA sponges, interacting with proteins, and even demonstrating translational capabilities to produce proteins. These diverse functions position circRNAs as key players in the complex landscape of the pathogenesis of various diseases, including liver disease. Unraveling the intricate involvement of circRNAs in these liver disorders provides valuable insights into their diagnostic and therapeutic potential. This chapter aims to comprehensively examine the current body of literature, consolidating our understanding of the complex regulatory networks orchestrated by circRNAs in liver pathophysiology. Additionally, it strives to identify potential avenues for therapeutic intervention and diagnostic innovation, thus contributing to the burgeoning field of precision medicine in liver disease management.
Indexed as
Identifiers
40886286What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.