ArticleJournal of health, population, and nutrition2025
Nutritional-inflammatory balance assessed by advanced lung cancer inflammation index and its association with all-cause mortality in coronary heart disease : a retrospective cohort study.
Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Advanced lung cancer inflammation index and mortality risk in patients with cardiovascular disease.BMC cardiovascular disorders · 2026Article
- Prognostic significance of the advanced lung cancer inflammation index for long-term mortality in patients with acute myocardial infarction and diabetes.Frontiers in endocrinology · 2026Article
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Authors and funding
5 authors.
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Abstract
objectiveThe present study aimed to evaluate the association between advanced lung cancer inflammation index (ALI) and all-cause mortality in a population of patients with Coronary Heart Disease(CHD) using a retrospective cohort study design.
methodsData were obtained from the 1999-2018 National Health and Nutrition Examination Survey (NHANES). ALI was calculated as BMI × albumin level ÷ NLR, integrating anthropometric, nutritional, and inflammatory biomarkers. History of CHD was obtained using a questionnaire. We used Cox regression analysis to explore potential relationships and examined the nonlinear relationship using Restricted Cubic Splines (RCS).
resultsA total of 1,295 participants were included in the study. Cox regression results revealed that a higher ALI was associated with lower all-cause mortality in patients with CHD. The subgroup and interaction analyses showed that the results were consistent. After adjusting for all covariates, participants in quartile 4 of ALI showed a 39% reduction in all-cause mortality compared to quartile 1. RCS analysis indicates a U-shaped relationship with a breaking point of 117.33.
conclusionIn the United States, higher ALI was associated with lower all-cause mortality among patients with CHD. These findings suggest a potential association between ALI and all-cause mortality in CHD patients that warrants further investigation in prospective studies. Future interventional studies are needed to determine whether strategies targeting the components of ALI could improve clinical outcomes in this population.
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