Observational studyEuropean journal of medical research2025
Reduced phosphatidylcholine and phosphatidylethanolamine levels correlate with inflammatory activation in sepsis-associated encephalopathy.
Observational study in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04230447 (Peking Union Medical College Hospital), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peking Union Medical College Hospital
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical lipidomics in bacterial sepsis: a systematic review of serum and plasma evaluations.Metabolomics : Official journal of the Metabolomic Society · 2026Pooled it
- Widely targeted metabolomics and machine learning identify succinate as a key metabolite in sepsis-associated encephalopathy.iScience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSepsis-associated encephalopathy (SAE) is a severe complication of sepsis, often leading to poor neurological outcomes. Lipid molecules are increasingly recognized for their potential involvement in both sepsis and cognitive impairment. However, the relationship between lipidomic alterations and SAE remains incompletely understood. This study aims to investigate lipidomic changes in patients with SAE and explore potential associations between lipid metabolism and the development of SAE.
methodsSepsis patients without pre-existing central nervous system disorders were prospectively enrolled. SAE was defined as a positive result on the Confusion Assessment Method for the ICU (CAM-ICU) or a Glasgow Coma Scale (GCS) score < 15. Blood samples were collected at enrollment and upon any change in cognitive status. Cerebrospinal fluid (CSF) samples were collected based on the physician assessment. Lipid metabolites were analyzed using high-performance liquid chromatography coupled with mass spectrometry.
resultsA total of 98 sepsis patients were enrolled, with 39 classified into the SAE group and 59 into the non-SAE group. Plasma levels of phosphatidylethanolamines (PE) and phosphatidylcholines (PC) were significantly decreased in SAE patients. Among these, LPC (18:2), LPC (16:0), LPE (22:6), and LPE (20:4) showed the most notable reductions. Additionally, 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) levels were decreased in SAE patients, while proinflammatory cytokines such as IFN-γ, IL-1ra, MCP-1, and IP-10 were elevated.
conclusionReduced levels of PC and PE lipids in SAE patients may reflect underlying inflammatory processes. The observed downregulation of HMG-CoA and upregulation of IP-10 and MCP-1 suggest a potential therapeutic role for statins in the management of SAE. Clinical Trial Registry number and website where it was obtained: Clinical Trial NCT04230447 (Registration Date: 01/02/2021; https://www. CLINICALTRIALS: gov/study/NCT04230447?cond=Sepsis%20Associated%20Encephalopathy&rank=4 ).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.