ArticleAnnals of medicine2025
A 5-week low-dose prednisolone regimen for progressive vitiligo: efficacy and safety in a single-center cohort study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundProgressive vitiligo lacks standardized glucocorticoid regimens, with prolonged treatments often causing adverse effects. This study evaluated a novel 5-week low-dose prednisolone strategy (0.5 mg/kg/day, tapered weekly) to balance efficacy and safety.
objectiveTo assess the efficacy and safety of this regimen in halting disease progression and inducing repigmentation in progressive vitiligo.
methodsIn this single-center retrospective cohort study (January 2017 to January 2022), 319 progressive vitiligo patients (Vitiligo Disease Activity score, VIDA score ≥ +2) received the 5-week regimen. Outcomes included treatment efficacy (cessation of progression ± repigmentation), adverse events, and patient satisfaction (visual analog scale, VAS).
resultsThe efficacy rate was 88.71% (283/319), with 63.60% (180/283) achieving repigmentation (grade 1: 56.7%, grade 2: 25.6%, grade 3: 11.1%, grade 4: 6.7%). Disease severity significantly correlated with treatment response (
conclusionThis 5-week low-dose prednisolone regimen rapidly stabilizes progressive vitiligo across ages and subtypes, with high efficacy, minimal adverse effects, and excellent patient compliance. It offers a practical alternative to prolonged steroid protocols, particularly for early intervention.
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