ArticleDiabetes, obesity & metabolism2025
Relationship of intra-pancreatic fat deposition with low-density lipoprotein subfractions and hepatic lipase.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Validation of magnetic resonance imaging for quantification of intrapancreatic fat deposition using phantom and histologic comparators: a systematic review and meta-analysis.European radiology · 2026Pooled it
- Identification of Common Blood Metabolic Derangements Using Magnetic Resonance Signatures of the Pancreas and Liver.Diabetes, obesity & metabolism · 2026Article
- Article
- Relationship of intra-pancreatic fat deposition with low-density lipoprotein subfractions and hepatic lipase.Diabetes, obesity & metabolism · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimTo investigate the associations of intra-pancreatic fat deposition (IPFD) with low-density lipoprotein (LDL) subfractions and hepatic lipase. MATERIALS AND
methodsIPFD was quantified using a single 3.0 Tesla magnetic resonance imaging scanner. LDL subfractions were assessed with a commercially available system employing non-denaturing polyacrylamide gel electrophoresis. The LDL profile included six subfractions, grouped into two subclasses: large LDL (LDL-1 and LDL-2) and small LDL (LDL-3 to LDL-6). Univariate and multivariate linear regression analyses were conducted to examine associations, with adjustments made for age, sex, ethnicity, obesity, insulin resistance and triglyceride levels.
resultsA total of 174 individuals were included in the analysis. IPFD was not significantly associated with any LDL subfraction or subclass in any of the statistical models. Similarly, hepatic lipase showed no significant association with IPFD. However, hepatic lipase was significantly and inversely associated with the LDL-1 and LDL-2 subfractions, as well as the LDL-large subclass, across all three statistical models. In the most adjusted model, each unit increase in hepatic lipase was associated with a 0.24-unit decrease in LDL-1 (p = 0.002), a 0.22-unit decrease in LDL-2 (p = 0.003) and a 0.27-unit decrease in the LDL-large subclass (p < 0.001).
conclusionsThe lack of a significant association between IPFD and LDL subfractions suggests that the link between IPFD and cardiovascular disease is likely mediated through mechanisms other than alterations in LDL particle distribution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.