Evidence map›Paper›PMID 40889617›Full record

ArticleNeuropharmacology2025

Using in vivo MRI to reveal circuits that are sensitive to traumatic stress in male and female rats.

Negin Mohammadmirzaei, Praveen Kulkarni, Matt Biddle, Xuezhu Cai, Khan Hekmatyar, Dayan Knox

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Negin MohammadmirzaeiDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE, USA.
Praveen KulkarniDepartment of Psychology, Northeastern University, Boston, MA, USA.
Matt BiddleDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE, USA.
Xuezhu CaiDepartment of Psychology, Northeastern University, Boston, MA, USA.
Khan HekmatyarAdvanced Translational Imaging Facility, Georgia State University, Atlanta, GA, USA.
Dayan KnoxDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE, USA. Electronic address: dayank@udel.edu.

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Updated confocal microscope in the Imaging Core facility to support biomedical researchP20GM103653 · NIGMS · DELAWARE STATE UNIVERSITY · PI HARRINGTON, MELISSA A · 2012 to 2022
$22.7M
NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM103653
6 · The paper itself

Abstract

backgroundPost traumatic stress disorder (PTSD) is debilitating and more prevalent in women than men. While this suggests there are sex differences in the way neural systems respond to traumatic stress, identifying these systems are challenging. As such, studies designed to identify neural systems that are differentially sensitive to traumatic stress are needed.

methodsWe examined the impact of traumatic stress within a rat model (single prolonged stress (SPS)) on resting-state functional connectivity (rs-FC) and anatomical volume using in vivo MRI. Rs-FC and anatomical volume were measured before and after application of stress in male and female rats. Algorithmic, clustering, and GLM approaches were used to characterize how SPS changed rs-FC and volume across multiple neural systems.

resultsSPS decreased rs-FC within the DMN, within the hippocampus (Hipp), and increased rs-FC between the thalamus (th) and striatum. Changes in th-Hipp connectivity brought on by SPS were different in males and females, with decreased rs-FC between the mediodorsal thalamus (thMD) and ventral CA1 (vCA1) occurring in males, and increased rs-FC between the paraventricular thalamic nucleus (PV) and vCA1, and thMD and the dorsal dentate gyrus (dDG), occurring in female rats. In control rats dDG volume expanded from the pre-to post-stress scans and this expansion was inhibited in SPS animals.

conclusionsThe results of this study raise the possibility that sex differences in traumatic stress responsivity could manifest through thalamo-Hipp circuits. The results also raise the possibility that traumatic stress may inhibit natural volumetric expansions within the Hipp.

Indexed as

BrainNerve NetSex CharacteristicsStress Disorders, Post-TraumaticStress, PsychologicalAnimalsFemaleMagnetic Resonance ImagingMaleNeural PathwaysRatsRats, Sprague-DawleyThalamusDMNHippocampusMediodorsal thalamusParaventricular thalamic nucleusPTSDSex differences

Identifiers

PMID40889617
PMCPMC12536720

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.