SynthesisScientific reports2025
A systematic review and dose-response meta-analysis of red blood cell distribution width to albumin ratio as mortality predictor in cardiovascular disease.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of hyperhomocysteinemia in South Asian patients with heart disease: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- The incremental prognostic effect of red blood cell distribution width in 28-day mortality among critically ill patients with HFpEF.American heart journal plus : cardiology research and practice · 2026Article
- Red cell distribution width-to-albumin ratio predicts mortality in critically ill patients with gastrointestinal bleeding: A retrospective cohort study with external validation.The Journal of international medical research · 2026Article
- Associations of the C-Reactive Protein-Albumin-Lymphocyte Index, Red Cell Distribution Width-Albumin Ratio, and Blood Urea Nitrogen-Albumin Ratio With All-Cause and Cardiovascular Mortality Among Adults With Preclinical Heart Failure.Clinical cardiology · 2026Article
- Association of the RDW-to-albumin ratio with MAFLD and hepatic fibrosis in the U.S. population: a national cross-sectional study.Clinical and experimental medicine · 2026Article
- The role of red blood cell distribution width in prognosis prediction among critically ill patients with obstructive sleep apnea: Insights from the MIMIC-IV database.Scientific reports · 2026Article
- Prognostic value of albumin-related inflammatory ratios for 30-day mortality in rheumatic heart disease: a dual-cohort study with external validation.Frontiers in nutrition · 2026Article
- Red cell distribution width to albumin ratio (RAR) as a predictor of clinical outcomes and in-hospital mortality in acute gastrointestinal bleeding: a retrospective analysis.Proceedings (Baylor University. Medical Center) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Red blood cell distribution width (RDW) and albumin separately have been used as mortality predictors for people with cardiovascular disease (CVD). This study aims to explore whether the RDW-to-albumin ratio (RAR) could provide a better prognostication in the CVD population. A systematic search of suitable studies was conducted in PubMed, Web of Science, Scopus, and ProQuest until February 1, 2024. Mortality and length of stay outcomes of the highest vs. lowest RAR tertile were pooled using hazard ratio (HR) and standardized mean difference (SMD), respectively. Additionally, a dose-response meta-analysis was performed. Publication bias, subgroup, and sensitivity analyses were conducted to address the causes of heterogeneity. Sixteen studies with 30,933 participants were included in the meta-analysis. Pooled results showed that patients with higher RAR faced a significantly higher risk of mortality (HR 1.88, 95%CI 1.59-2.23). Nonlinearity was observed in the dose-response relationship. Using a reference value of 3 ml/g, each 1 ml/g increase in RAR corresponded to a 27% rise in the mortality HR (HR 1.27, 95%CI 1.16-1.39). Our study demonstrated that elevated RAR values were significantly associated with higher mortality in CVD and exhibited a positive dose-response relationship, suggesting its potential as a novel prognostic biomarker for CVD.
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