Evidence map›Paper›PMID 40890422›Full record

ArticleScientific reports2025

Thrombus enhancement as a predictor of embolic in acute basilar artery occlusion.

Kun Tang, Kunxin Lin, Baoming Lei, Jia Li, Haifeng Liu, Yi Yang, Wenhua Liu, Wenlong Zhao, Zhangbao Guo

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kun Tang *Department of Neurology, Wuhan No. 1 Hospital, Wuhan, China.
Kunxin Lin *Department of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, Fujian, China.
Baoming LeiDepartment of Neurology, Wuhan No. 1 Hospital, Wuhan, China.
Jia LiDepartment of Neurology, Wuhan No. 1 Hospital, Wuhan, China.
Haifeng LiuDepartment of Neurology, Wuhan No. 1 Hospital, Wuhan, China.
Yi YangDepartment of Neurology, Wuhan No. 1 Hospital, Wuhan, China.
Wenhua LiuDepartment of Neurology, Wuhan No. 1 Hospital, Wuhan, China.
Wenlong ZhaoDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, Fujian, China.
Zhangbao GuoDepartment of Neurology, Wuhan No. 1 Hospital, Wuhan, China. gzb119@163.com.

Funding

the Project of University-Industry-Research Joint Innovation of Fujian Province 2023Y4016the Youth Project of Hubei Provincial Administration of Traditional Chinese Medicine ZY2025Q020
6 · The paper itself

Abstract

Thrombus enhancement sign (TES) is a potential imaging biomarker for differentiating embolic large vessel occlusion (embo-LVO) from intracranial atherosclerosis-related LVO (ICAS-LVO) in basilar artery occlusion (BAO). This study evaluates the association between TES and BAO etiology and its predictive value in distinguishing embo-LVO from ICAS-LVO. We conducted a prospective, two-center cohort study of acute ischemic stroke (AIS) patients with BAO who underwent EVT between January 2020 and September 2024. TES was assessed using thin-section maximum intensity projection (TS-MIP) CTA. Patients were classified as embo-LVO or ICAS-LVO based on post-EVT angiography. Logistic regression, receiver operator characteristic curve (ROC) and DeLong test were used to assess TES's diagnostic accuracy. Among 107 patients, TES was detected in 56.1% (60/107). TES was significantly more frequent in embo-LVO (85.2%) than in ICAS-LVO (17.4%) (p < 0.001). TES significantly associated with embo-LVO (OR, 16.136; 95% CI 4.672-55.733; p < 0.001). The area under the curve (AUC) of TES for embo-LVO was 0.839, outperforming distal BAO (AUC = 0.714, p = 0.02). Combining TES with distal BAO improved predictive accuracy (AUC = 0.883). TES is a reliable marker for identifying embo-LVO in BAO and enhancing endovascular treatment strategies for AIS.

Indexed as

Basilar ArteryIschemic StrokeThrombosisVertebrobasilar InsufficiencyAgedAged, 80 and overComputed Tomography AngiographyFemaleHumansIntracranial ArteriosclerosisMaleMiddle AgedProspective StudiesROC CurveAcute ischemic strokeBasilar artery occlusionEndovascular therapyLarge vessel occlusionThrombus enhancement sign

Identifiers

PMID40890422
PMCPMC12402210

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.