ArticleBMC musculoskeletal disorders2025
Low-Intensity pulsed ultrasound enhances paracrine secretion of IGF and VEGF by bmscs, promoting osteogenesis and angiogenesis.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Low-intensity ultrasound induces angiogenesis by activating endothelial integrin signaling in male mice.Physiological reports · 2026Article
- Combined Stromal Vascular Fraction and HGF-Functionalized Self-Assembling Peptide Hydrogel Improves Intracerebral Hemorrhage Repair in Rats.Gels (Basel, Switzerland) · 2026Article
- Mitochondria-Targeted Biophysical Priming of Autologous Biologics for Skin Regeneration and Wound Repair.International journal of molecular sciences · 2026Review
- The Role of Phagocytic Cells in the Achilles Tendon.International journal of molecular sciences · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundLow-intensity pulsed ultrasound (LIPUS) is an effective therapy for craniofacial bone regeneration. Paracrine signaling from mesenchymal stem cells (MSCs) plays a critical role in bone repair, but the impact of LIPUS on MSC-derived secretome remains unclear. This study investigates whether LIPUS enhances the osteogenic and angiogenic potential of MSCs through modulation of growth factor secretion.
methodsBone marrow-derived MSCs (BMSCs) were treated with or without LIPUS to generate conditioned media (LIPUS-CM and Ctrl-CM). Concentrations of IGF-1, VEGF, and TGF-β were quantified. These media were applied to other BMSCs and rat aortic endothelial cells (RAOECs). In vitro assays evaluated cell proliferation, migration, osteogenic differentiation, and angiogenesis. Data were analyzed using GraphPad and Image J, with significance set at α = 0.05.
resultsLIPUS significantly upregulated IGF-1 and VEGF secretion in BMSCs, while TGF-β levels remained unchanged. RAOECs cultured in LIPUS-CM demonstrated enhanced proliferation, migration, and angiogenic capacity. Likewise, BMSCs cultured in LIPUS-CM showed improved proliferation, migration, and osteogenic differentiation compared to the Ctrl-CM group.
conclusionLIPUS promotes osteogenic differentiation of BMSCs and angiogenesis in RAOECs through the paracrine signaling of BMSCs, at least by increasing IGF-1 and VEGF secretion. This suggests that LIPUS can regulate the secretome of BMSCs and may serve as a key mechanism in promoting bone tissue regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.