ReviewInfectious agents and cancer2025
Prevalence and genotype distribution of human papillomavirus (HPV) infections among West African populations: a systematic review and meta-analysis.
Review in Infectious agents and cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of cervical human papillomavirus infection among women in Ghana: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Immunological Determinants of Oncogenic Virus-Driven Cancers in Africa: Mechanisms, Co-Infections and Public Health Challenges.Pathogens (Basel, Switzerland) · 2026Review
- Article
- Mapping the HPV Detection Landscape in Botswana: A Narrative Review of Diagnostic Platforms and Their Impact on Cervical Cancer Control.Health science reports · 2026Article
- Gaps and barriers preventing sustained delivery of HPV vaccination in Kano, Kaduna, and Lagos states: An exploratory qualitative study.PloS one · 2026Article
- From dysbiosis to mechanisms: Why cervicovaginal microbiome-HPV studies must catch up with biology.PLoS pathogens · 2025Article
- HPV, APOBEC3B, and the origins of breast cancer: a narrative review and perspectives on novel mechanisms.Frontiers in oncology · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Several studies have examined HPV prevalence in West Africa, but comprehensive regional estimates remain unavailable. This study estimates the overall prevalence and genotype distribution of HPV in West African populations.
methodsWe conducted a systematic search in Medline, Embase, Global Health, Web of Science, and Africa Index Medicus for articles published up to March 5, 2024. We estimated pooled HPV prevalence using a random-effects model. The Hoy et al. tool assessed the risk of bias, while the I² test measured between-study heterogeneity. Egger's regression test evaluated publication bias. The study was registered with PROSPERO (CRD42023463042).
resultsThe analysis included 145 studies from 12 West African countries, comprising 71,324 participants. The pooled prevalence of HPV was 42.3% (95% CI: 38.5-46.1%), with significant heterogeneity (I² = 99.0%; P < 0.001). HPV prevalence varied across population subgroups, with a significantly higher pooled prevalence of 81.4% (95% CI: 68.2-91.8%) among women with cervical cancer. Egger's test did not indicate significant publication bias (P > 0.05). Among high-risk HPV genotypes, HPV-16 (19.9%, 95% CI: 15.9-24.1%) and HPV-82 (18.9%, 95% CI: 7.5-33.7%) were the most prevalent. Among low-risk genotypes, HPV-81 was the most common, with a prevalence of 12.9% (95% CI: 7.1-20.0%).
conclusionHuman papillomavirus prevalence is high in West Africa, with diverse genotypes, including several with oncogenic potential. Targeted health interventions, including vaccination programs and enhanced screening efforts, are recommended to reduce HPV burden in this region.
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