ArticleTropical medicine and health2025
Molecular containment of iron source inhibits larval survival of Schistosoma mansoni and egg-laying behavior of the female adult worms via ovarian atrophy.
Article in Tropical medicine and health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSchistosomiasis is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma. Currently, praziquantel is the only medication available for treating schistosomiasis. However, crucial issues regarding drug resistance, reinfection, and prevention remain unresolved. Therefore, it is indispensable to develop new antischistosomal drugs, whose mechanisms of action are distinct from that of praziquantel. This diversification in treatment is vital to promote the eradication of schistosomiasis.
methodsIn this study, to explore the untapped antischistosomal compounds against Schistosoma species, which have diverse life cycles, we initially investigated the effects of a series of phenanthroline-based compounds (PHN-X) with iron-binding affinity on the survival capacity of Schistosoma mansoni larvae and egg production by paired adult worms in vitro. Subsequently, we examined the impacts of PHN-X on the egg production and fecundity of female adult worms in vivo, following oral administration of them to mice infected with S. mansoni cercariae. Finally, we conducted a morphological analysis of the reproductive organs of the female adult worms after treating S. mansoni-infected mice with a newly identified compound with high anti-fecundity effect.
resultsThe assay for determining IC
conclusionsPHN-(OMe)
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