ArticleMilitary Medical Research2025
Sepsis in burn care: incidence and outcomes.
Article in Military Medical Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The cellular response capacity (CRC) as a novel immunomonitoring approach in sepsis.Military Medical Research · 2026Article
- Infections in Burn Patients: Pathophysiology, Prevention, and Contemporary Therapeutic Strategies in the Era of Antimicrobial Resistance.Infectious diseases and therapy · 2026Review
- [Current applications and prospects of artificial intelligence in burn diagnosis and treatment].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Serious Infections in Burn-Injured Adults: A Retrospective Single-Center Study from 1997 to 2023.Journal of burn care & research : official publication of the American Burn Association · 2026Article
- Endocrine disruptions in thermal injuries: exploring immune system interactions.Physiological reviews · 2026Review
- Challenges in Antimicrobial Treatment and Antimicrobial Stewardship in Hospital-Acquired Infections in Adult Burn Patients.European burn journal · 2026Review
- Longitudinal biomarker trajectories and their prognostic utility for 21-day mortality in burn patients with sepsis: a retrospective cohort study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Beyond wound closure: translational opportunities and barriers of mesenchymal stem cells and their extracellular vesicles in burn management.Frontiers in cell and developmental biology · 2026Review
- Sepsis in burns: lessons learned, challenges remain.Military Medical Research · 2025Article
- [Application of multidisciplinary team diagnosis and treatment model in the management of patients with combined burns and heat stroke].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Observational
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough sepsis is known to be the leading cause of morbidity and mortality in adult burn patients, its epidemiology and impact are poorly understood. This study aims to address these gaps by further characterizing predictors of sepsis and comparing outcomes between septic and non-septic burn patients in different age groups.
methodsWe included patients (≥ 18 years) with thermal burn injuries ≥ 5% total body surface area (TBSA) admitted to two burn centers between 1 January 2006 and 30 June 2021, and 1 January 2023 and 6 April 2025. Patients were stratified by age into adults (18-59 years) and older adults (≥ 60 years), and by diagnosis of sepsis during hospitalization (sepsis vs. control). Demographics, injury characteristics, mortality, and in-hospital complications were assessed. Multivariate logistic regression models were used to identify predictors of sepsis and mortality among septic patients.
resultsThis study included a total of 1465 patients, including 1094 adults and 371 older adults. Sepsis was diagnosed in 20.1% of adult burn patients, with a median onset at 10 d following injury. Increasing age, greater TBSA, and inhalation injury were identified as significant risk factors for sepsis. Among patients who developed sepsis, earlier onset and female sex were associated with an elevated risk of mortality. In older adults, the incidence of sepsis was 22.9%, with a median onset at 11 d post-burn. The odds of sepsis diagnosis increased with higher TBSA and the presence of inhalation injury. Earlier sepsis onset was associated with increased mortality in older adults.
conclusionsSepsis represents a significant clinical challenge in burn patients, with age, TBSA, inhalation injury, and comorbidities significantly influencing its incidence and outcomes. Notably, early sepsis onset and female sex are associated with increased mortality, highlighting the need for advanced monitoring, prompt interventions, and the exploration of innovative sex-specific strategies to optimize outcomes in this high-risk population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.