ArticleClinical science (London, England : 1979)2025
Impact of the natural female reproductive aging on the rat serum lipidome.
Article in Clinical science (London, England : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Early-life cognitive intervention preserves brain function in aged TgF344-AD rats with sex-specific effects.iScience · 2026Article
- Recombinant humanized type III collagen improves ovarian function via ITGA2-mediated mitochondrial function restoration in granulosa cells and extracellular matrix remodeling.Regenerative biomaterials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Perimenopause is a transitional phase leading to female reproductive senescence, which can cause vasomotor symptoms and increase the risk of osteoporosis, obesity, and metabolic-related disturbances in middle-aged and older women. Nevertheless, little is known regarding the underlying mechanisms linked to menopausal transition, which could be of great value in designing new interventions addressed to improve the health of both perimenopausal and postmenopausal women. We used an ovarian-intact middle-aged model of rats resembling the characteristics of human perimenopause and applied liquid and gas chromatography quadrupole time-of-flight mass spectrometry approaches for the determination of polar and lipid-related metabolites to identify characteristic circulating signatures across perimenopause. The gradual loss of regularity in the estrous cycle occurring during the natural transition to reproductive senescence was associated with altered circulating levels of estradiol, progesterone, and luteinizing hormone (LH) and, in rats that were in an acyclic state, with ovary atrophy and with a lack of stromal luteinization and corpus luteum. These results were accompanied by progressively significant changes in the 144 lipid-related metabolites detected in serum as the estrous cycles were losing regularity. Furthermore, we identified 18 lipid-related metabolites-including 9 phosphatidylcholines, 4 lysophosphatidylcholines, 2 phosphatidylethanolamines, cholesterol ester (18:2), 5α-androstane-3,17-diol, and 17,18-dihydroxyarachidonic acid-that already changed with the transition from a regular to an irregular estrous cycle and anticipated the changes in blood progesterone, LH, and cholesterol levels that occurred in acyclic rats. These metabolites could be used as a potential multivariate biomarker of early perimenopause. The translational applicability of these findings deserves further research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.