Evidence map›Paper›PMID 40891353›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Inhibition mechanism and behaviour of wedelolactone against α-glucosidase.

Jianjun Zhang, Min Zhao, Fan Wu, Zheng Shi, Rui Xie

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jianjun ZhangDepartment of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.ORCID 0000-0003-3313-2387
Min ZhaoDepartment of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.
Fan WuDepartment of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.ORCID 0009-0000-6015-8158
Zheng ShiDepartment of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.ORCID 0000-0001-6422-6461
Rui XieDepartment of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.ORCID 0000-0002-0910-5701

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The quest for effective and safe treatments for diabetes mellitus has led to the exploration of natural metabolites as potential α-glucosidase inhibitors. This study delves into the inhibition mechanism of wedelolactone against α-glucosidase and its hypoglycaemic activity. Activity assay results discovered that wedelolactone functioned as a mixed-type inhibitor, with an IC

Indexed as

alpha-GlucosidasesCoumarinsGlycoside Hydrolase InhibitorsHypoglycemic AgentsDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesCoumarinsGlycoside Hydrolase InhibitorsHypoglycemic Agentswedelolactoneinhibition mechanismWedelolactoneα-Glucosidase

Identifiers

PMID40891353
PMCPMC12406323

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.