Trial reportAnaesthesiology intensive therapy2025
iPACK block with adductor canal block vs. lumbar erector spinae plane block (L-ESPB) in total knee arthroplasty: a randomized, double-blinded, controlled trial.
Trial report in Anaesthesiology intensive therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Combined iPACK and adductor canal block versus two-level erector spinae plane block in elderly patients undergoing total knee arthroplasty: a randomized, triple-blinded clinical trial.Archives of orthopaedic and trauma surgery · 2026Trial
- Motor-Sparing Regional Analgesia in Frail and Sarcopenic Older Adults Undergoing Total Knee Arthroplasty: From Anatomy to Clinical Decision-Making-A Narrative Review.Journal of clinical medicine · 2026Review
- Dexamethasone vs. Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Total Knee Arthroplasty: A Randomized Double-Blind Controlled Trial.Journal of clinical medicine · 2026Article
- Ultrasound-Guided Regional Anesthesia: A Narrative Review of Techniques, Safety, and Clinical Applications.Cureus · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTotal knee arthroplasty (TKA) is associated with severe pain. We examined whether an ultrasound-guided, single-injection L2 erector spinae plane block could improve analgesia compared to an ultrasound-guided iPACK (infiltration between the popliteal artery and capsule of the knee) block with adductor canal block (ACB) in patients undergoing TKA under spinal anesthesia. MATERIAL AND
methodsNinety patients aged 65-89 years of both sexes (ASA I-III) scheduled for TKA were randomly allocated to receive iPACK block (ropivacaine 0.2%, 20 mL) with ACB (ropivacaine 0.2%, 10 mL), lumbar erector spinae plane block (L-ESPB) (ropivacaine 0.2%, 20 mL on each side), or to the control group. The primary outcome was total opioid consumption. The secondary outcomes included pain scores, time to first rescue opioid analgesia, quadriceps muscle strength, neutrophil-to-lymphocyte ratio (NLR), and platelet- to-lymphocyte ratio (PLR).
resultsThe total opioid consumption in 48 h was significantly lower in the iPACK+ACB group (mean ± SD) (3.0 ± 3.3) compared to L-ESPB (6.8 ± 3.8,
conclusionsThe iPACK+ACB is more effective than L-ESPB in pain management following TKA. iPACK+ACB and the L-ESPB lowered total opioid consumption and prolonged time to first opioid analgesia. NLR and PLR levels did not differ between the groups.
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