Evidence map›Paper›PMID 40892009›Full record

ArticleAging2025

Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity.

Daniel R Machin, Md Torikul Islam, Alec Malouf, Daniel Nguyen, Mostafa Sabouri, Maryana Boulos, Andrew G Horn, Kiana M Schulze, Gwenael Layec, Lisa A Lesniewski and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel R MachinDepartment of Cell Biology and Physiology, Vascular Physiology Group, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Md Torikul IslamDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.
Alec MaloufDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Daniel NguyenDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Mostafa SabouriDepartment of Cell Biology and Physiology, Vascular Physiology Group, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Maryana BoulosDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Andrew G HornDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Kiana M SchulzeDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Gwenael LayecDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Lisa A LesniewskiDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Anthony J DonatoDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.

Funding

Integrative Mechanisms of Vascular AgingR01AG077751 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$450k
BLRD VA I01 BX004492NCCIH NIH HHS R00 AT010017NIA NIH HHS F31 AG076312NIA NIH HHS K02 AG045339NIA NIH HHS R01 AG048022NIA NIH HHS R01 AG048366NIA NIH HHS R01 AG050238NIA NIH HHS R01 AG077751
6 · The paper itself

Abstract

Age-related declines in cardiovascular function contribute to reduced physical capacity, both of which are independent predictors of mortality. We have previously demonstrated that glycocalyx-targeted therapy with Endocalyx™ that contains high-molecular-weight hyaluronan (HMW-HA) improves cardiovascular health in old age, raising the possibility that HMW-HA also plays a role in age-related physical dysfunction. Here, we first demonstrate that tamoxifen-inducible deletion of

Indexed as

AgingExercise ToleranceGlycocalyxHyaluronic AcidSarcopeniaAnimalsDietary SupplementsMaleMiceMice, KnockoutMitochondria, MuscleMuscle, SkeletalPhysical Conditioning, AnimalHyaluronic Acidagingglycocalyxhyaluronan

Identifiers

PMID40892009
PMCPMC12517214

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.