Evidence map›Paper›PMID 40892085›Full record

ReviewPediatric radiology2025

White paper on the current state of imaging biomarkers in paediatric oncology.

Rutger A J Nievelstein, Lise Borgwardt, Emilio J Inarejos Clemente, Thekla Von Kalle, Martin Kyncl, Maarten H Lequin, Annemieke S Littooij, Erika Pace, Pier L Di Paolo, Rick R Van Rijn and 7 more

Abstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rutger A J NievelsteinDepartment of Radiology and Nuclear Medicine, Division Imaging and Oncology, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85500, 3508, GA, Utrecht, Netherlands. r.a.j.nievelstein@umcutrecht.nl.
Lise BorgwardtDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Emilio J Inarejos ClementeDepartment of Diagnostic Imaging, Nuclear Medicine and Interventional Radiology, Sant Joan de Déu Barcelona Children's Hospital, Barcelona, Spain.
Thekla Von KalleRadiological Institute, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany.
Martin KynclDepartment of Radiology and Center for Pediatric Neuro-Oncology, Second Faculty of Medicine, Charles University Prague and University Hospital in Motol, Prague, Czech Republic.
Maarten H LequinEdward B. Singleton Department of Radiology, Texas Children's Hospital and Baylor College of Medicine, Houston, United States.
Annemieke S LittooijDepartment of Radiology and Nuclear Medicine, Division Imaging and Oncology, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85500, 3508, GA, Utrecht, Netherlands.
Erika PaceDepartment of Radiology, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom.
Pier L Di PaoloDepartment of Radiology, Bambino Gesù Children's Hospital, Rome, Italy.
Rick R Van RijnDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, Netherlands.
Julian M M RogaschDepartment of Nuclear Medicine, Charité - University Medicine Berlin, Berlin, Germany.
Jurgen SchäferDivision of Pediatric Radiology, Department of Radiology, Universitätsklinikum Tübingen, Tübingen, Germany.
Irmina Sefic PasicDepartment of Radiology, University Medical Center Maribor, Maribor, Slovenia.
Anita SpezzacateneRadiology Department, IRCCS Materno Infantile Burlo Garofolo, Trieste, Italy.
Nelleke TolboomDepartment of Radiology and Nuclear Medicine, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Simon M WanInstitute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Pietro ZucchettaNuclear Medicine Department, University Hospital of Padua, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.

Indexed as

BiomarkersBiomarkers, TumorDiagnostic ImagingMedical OncologyNeoplasmsPediatricsChildHumansSocieties, MedicalBiomarkersBiomarkers, TumorBiomarkersChildDiagnostic imagingNuclear medicineOncologyRadiologyRadionuclide imaging

Identifiers

PMID40892085
PMCPMC12602564

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.