Does GLUT4 Queue? A Mechanistic Mathematical Model for Insulin Response in Adipocytes.

Brock D Sherlock, Marko A A Boon, Maria Vlasiou, Adelle C F Coster

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Article in Bulletin of mathematical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Brock D SherlockSchool of Mathematics & Statistics, University of New South Wales, Sydney, 2052, NSW, Australia.

Marko A A BoonDepartment of Mathematics and Computer Science, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600 MB, The Netherlands.

Maria VlasiouFaculty of Electrical Engineering, Mathematics and Computer Science, University of Twente, P.O. Box 217, Enschede, 7500 AE, The Netherlands.

Adelle C F CosterSchool of Mathematics & Statistics, University of New South Wales, Sydney, 2052, NSW, Australia. A.Coster@unsw.edu.au.ORCID http://orcid.org/0000-0002-5572-6832

Funding

Australian Research Council DP210100255

6 · The paper itself

Abstract

Mammalian cells regulate their glucose levels by redistributing glucose transporter proteins within the cell. Glucose Transporter 4 (GLUT4) is the main insulin-regulated glucose transporter in mammalian cells. Insulin signals the redistribution of GLUT4 from intracellular compartments to the cell surface. The mechanisms of the release of GLUT4 and subsequent transport to the plasma membrane remain an open question. Here, a biologically plausible model of GLUT4 translocation is presented. Using a stochastic queuing model, we find that changing only the number of fusion sites available for GLUT4-containing vesicles as a function of insulin is sufficient to explain experimental observations. Thus, the activity of the fusion sites could be the primary determinant of the dynamics of GLUT4.

Indexed as

AdipocytesGlucose Transporter Type 4InsulinModels, BiologicalAnimalsCell MembraneHumansMathematical ConceptsProtein TransportStochastic ProcessesGlucose Transporter Type 4Insulin

Identifiers

PMID40892178

DOI10.1007/s11538-025-01490-6

PMCPMC12405404

What Socratic holds

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LicenceCC BY

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