ArticlePflugers Archiv : European journal of physiology2025
Enhancing the quantification of post-occlusive reactive hyperemia: a multimodal optical approach.
Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Reactive Hyperemia Reveals Fractal Scaling and Multiscale Complexity in Photoplethysmography Waveforms.Biology · 2026Article
- Optimizing In Vivo Perfusion Assessment by Laser Doppler Flowmetry-Effects of Probe Geometry and Signal Normalization.Diagnostics (Basel, Switzerland) · 2026Article
- Wavelet Components of Photoplethysmography During Reactive Hyperemia: Absolute vs. Relative Metrics.Biology · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-occlusive reactive hyperemia (PORH) is a physiological response marked by a transient increase in microvascular perfusion following ischemia. While cutaneous perfusion during PORH has been extensively characterized using optical approaches such as Doppler-based techniques, low-cost alternatives like photoplethysmography (PPG), videocapillaroscopy (VC) and near-infrared reflectance imaging (NIRI) may provide complementary insights into both microvascular and venous dynamics. However, their role in quantifying PORH remains underexplored. This study aimed to evaluate the potential of low-magnification VC and NIRI-based imaging for quantifying perfusion changes during a standardized PORH protocol in healthy subjects, using PPG as a reference. Fourteen participants (21.5 ± 4.2 years) underwent suprasystolic occlusion of a randomly selected upper limb, with simultaneous recordings using PPG and VC at the finger and NIRI at the dorsal hand veins. The protocol included a 5-min baseline, 3-min occlusion (200 mmHg), and 5-min recovery. Skin blood flow was derived from the PPG signal, a hemoglobin index (C
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